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London Welsh boss Lyn Jones has given his second string a chance to shine in Friday's Amlin Challenge Cup trip to Grenoble.
The Exiles need a victory at the Stade Lesdiguieres if they are to keep their hopes of a last-eight place alive.
They were crushed 68-19 at home by Stade Francais, and needed a late penalty to edge out I Cavalieri Prato 32-31.
Jones has made 14 changes from the team that beat London Irish in the Aviva Premiership, with only full-back Tom Arscott keeping his place.
The Top 14 side are most likely to threaten Stade at the top of Pool 5, having taken a losing bonus point from Paris in their last match.
However, Grenoble have never beaten English opposition in European action.
They were on the wrong end of a heavy defeat by Toulon in the Top 14 last weekend but they are going well in sixth place following promotion last season.
Grenoble: 15. Joaquim Tuculet, 14. Viliame Waqaseduadua, 13. Rida Jaouher, 12. Aloisio Butonidualevu, 11. Florian Ninard, 10. James Hart, 9. Clement Darbo, 1. Romain David, 2. Vincent Campo, 4. Thibault Rey, 5. Andrew Farley, 6. Fabien Alexandre, 7. Jonathan Best, 8. Flavein Nouhaillaguet
Replacements: 16. Anthony Hegarty, 17. Gregory Fabro, 18. Karim Kouider, 19. Alexandre Pollard, 20. Valentin Courrent, 21. Henri Vanderglas, 22. Blair Stewart, 23. Fabien Gengenbacher,
London Welsh: 15. Tom Arscott, 14. Phil MacKenzie, 13. James Lewis, 12. Seb Jewell, 11. Ashley Smith, 10. Alex Davies, 9. Nick Runciman, 1. Tom Bristow, 2. Greg Bateman, 3. Arthur Joly, 4. Adam Brown, 5. Matt Corker, 6. Lee Beach, 7. Michael Hills, 8. Alfie To'oala.
Replacements: 16. Willie Hafu, 17. Billy Moss, 18. James Tideswell, 19. Jonathan Mills, 20. Mike Denbee, 21. Matthew Keyte, 22. Simon Whatling, 23. Nick Scott
"We're still in the competition and this is a great opportunity for several players to stake their claim for Aviva Premiership selection," said Jones.
"Every game is important to us and we want to win every single match. We understand where we are now and we mustn't lose focus of where we want to be at the end of the season. All games are big games and we've got to take each one as they come.
"This group of players is extremely motivated and has really prepared well this week, so we're looking forward to a good performance.
"Grenoble are a bit like London Welsh, they got promoted and have dramatically changed their squad."
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