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Winger Mike Poole is poised to make his first start in more than a year for the Newport Gwent Dragons in Saturday's Amlin Challenge Cup clash against Mogliano having finally returned to full fitness after injury.
Poole, 26, has been sidelined since October 2011 after rapturing knee ligaments against Treviso and then suffering a further setback in pre-season.
Influential lock Andrew Coombs also returns from the treatment and takes his place in the Dragons starting XV on Saturday having recovered from a knee injury of his own.
In total Dragons coach Darren Edwards makes 11 changes to the side that was well beaten by Treviso in the RaboDirect PRO12 last time out.
Coombs forms part of a whole new front five in the pack, while in the three-quarters youngster Jack Dixon partners the experienced Andy Tuilagi in the centres.
Mogliano will be looking to keep things competitive after suffering heavy defeats in their first two outings in the competition.
A 71-7 thrashing on their debut appearance in the event against Bayonne was followed by a 59-12 hammering on home soil by Wasps and the Italian outfit will be hoping Saturday's clash is more of a contest.
Mogliano: 15 Ezio Galon, 14 Giovanni Benvenuti, 13 Enrico Ceccato, 12 Cristian Cerioni, 11 Marco Gazzola, 10 Edoardo Padovani, 9 Enrico Endrizzi; 1 Andrea Ceccato, 2 Agustin Costa Repetto, 3 Massimiliano Ravalle, 4 Jacopo Bocchi, 5 Enrico Pavanello, 6 Marco Barbini, 7 Meyer Swanepoel, 8 Edoardo Candiago
Replacements:16 Ivan Gianesini, 17 Laert Naka, 18 Gianluca Ceneda, 19 Federico Maso, 20 Nicola Corbanese, 21 Tommaso Boni, 22 Filippo Guarducci, 23 Alberto Lucchese
Dragons: 15 Tom Prydie, 14 Will Harries, 13 Jack Dixon, 12 Andy Tuilagi, 11 Mike Poole, 10 Lewis Robling, 9 Jonathan Evans; 1 Nathan Williams, 2 Sam Parry, 3 Tim Ryan, 4 Ian Nimmo, 5 Andrew Coombs, 6 Jevon Groves, 7 Lewis Evans, 8 Ieuan Jones
Replacements: 16 Hugh Gustafson, 17 Owen Evans, 18 Nathan Buck, 19 Rob Sidoli, 20 Tom Brown, 21 Wayne Evans, 22 Dan Evans, 23 Pat Leach
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Read the thoughts and opinions of Stuart Barnes with skysports.com