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London Irish welcome back Jonathan Joseph and David Paice from their England duties, as they prepare to face Gloucester in the Amlin Challenge Cup at the Madejski Stadium.
Joseph will take the 13 shirt, with Sailosi Tagicakibau moving from outside centre to inside centre.
Matt Garvey is named in the second row with Jamie Gibson coming into the back row and Halani Aulika starts at tighthead prop.
Meanwhile, Gloucester's Director of Rugby Nigel Davies has tweaked his starting line-up yet the strength in the squad is retained.
Following a run out on the wing at Saracens last weekend, Martyn Thomas returns to his usual full-back berth.
Shane Monahan takes over at left wing and Dan Robson replaces Jimmy Cowan at scrum half.
Nick Wood, Huia Edmonds and Shaun Knight make up a new look, yet experienced front row, with Tom Savage joining Jim Hamilton in the second row.
After appearing at number eight last weekend, Sione Kalamafoni moves back to the flank with Gareth Evans and Matt Cox and completing the back row.
London Irish:15. Tom Homer; 14. Topsy Ojo; 13. Jonathan Joseph; 12. Sailosi Tagicakibau; 11. Anthony Watson; 10. Ian Humphreys; 9. Darren Allinson; 8. Ofisa Treviranus; 7.Jamie Gibson; 6. Declan Danaher (Captain); 5. Matt Garvey; 4. Bryn Evans; 3. Halani Aulika; 2. David Paice; 1. Max Lahiff.
Replacements: 16. Scott Lawson; 17.Jerry Yanuyanutawa; 18.Leo Halavatau; 19. Kieran Low; 20. Chris Hala'ufia; 21. Guy Armitage; 22. Shane Geraghty; 23. Jack Moates.
Martyn Thomas; Charlie Sharples, Tim Molenaar, Freddie Burns, Shane Monahan; Tim Taylor, Dan Robson; Nick Wood, Huia Edmonds, Shaun Knight; Tom Savage, Jim Hamilton (capt); Sione Kalamafoni, Matt Cox, Gareth Evans
Replacements: Darren Dawidiuk, Dan Murphy, Rupert Harden, Will James, Ben Morgan, Dave Lewis, Mike Tindall, Rob Cook.
"Both sides are well placed in the group and the next two week's will go a long way to seeing which side goes through to the knock out stages. Gloucester are enjoying a good run this season and will be a difficult opposition tomorrow, so we will need to be at our best to get the result."
"It'll be interesting to see how they approach this game. Obviously they've got a lot to do in the league, and we still have big ambitions in the league ourselves.
"We're going to go pretty full on, as we do for every competition. We will change things up a little bit and give opportunities, but it's a strong team.
"They've done very well in their two games so far in this competition, and there's no doubt that the next two games will very much determine how the pool shapes up."
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|3||Mont de Marsan||6||10|
|Amlin Challenge Cup|
|Friday 17th May|
|Amlin Challenge Cup|
|Stade Francais 13 - 34 Leinster|
|Saturday 27th April|
|Leinster 44 - 16 Biarritz|
|Friday 26th April|
|Perpignan 22 - 25 Stade Francais|
|Saturday 6th April|
|Bath 20 - 36 Stade Francais|
|Friday 5th April|
|Wasps 28 - 48 Leinster|
|Perpignan 30 - 19 Toulouse|
|Thursday 4th April|
|Gloucester 31 - 41 Biarritz|
Read the thoughts and opinions of Stuart Barnes with skysports.com