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Danny Cipriani has been rewarded for his heroics off the bench against Cardiff with a starting berth in Sale's team to face Montpellier.
The former Wasps fly-half takes over from Nick Macloed at No 10 after inspiring a tremendous second-half fightback against the Blues last weekend.
His efforts, which included scoring his team's first try, helped Sale battle back from a 30-12 deficit to belatedly record their first win of the campaign.
The England international's selection is one of eight changes made by director of rugby Bryan Redpath for the Pool Six clash at Stade Yves du Manoir.
Sam Tuitupou and Richie Gray are both unavailable through injury but Tom Brady returns on the right wing after suspension, allowing Mark Jennings to switch to centre.
Montpellier, meanwhile, have named their strongest available line-up as they look to bounce back from their opening-weekend defeat to Toulon.
Mamuka Gorgodze and Fulgence Ouedraogo come in on the flanks while Agustin Creevy starts at hooker alongside prop Juan Figallo.
The Top 14 side also names a new centre pairing of Timoci Nagusa and Shontayne Hape outside half-backs Julien Tomas and Francois Trinh-Duc.
Montpellier: 15 Lucas Amorosino, 14 Pierre Bérard, 13 Timoci Nagusa, 12 Shontayne Hape, 11 Martin Bustos Moyano, 10 Francois Trinh-Duc, 9 Julien Tomas, 8 Johnnie Beattie, 7 Mamuka Gorgodze, 6 Fulgence Ouedraogo, 5 Thibaut Privat, 4 Aliki Fakate, 3 Maximiliano Bustos, 2 Agustin Creevy, 1 Juan Figallo.
Replacements: 16 Rassie van Vuuren, 17 Yvan Watremez, 18 Vincent Pelo, 19 Mickael Demarco, 20 Alexandre Bias, 21 Benoit Paillaugue, 22 Santiago Fernandez, 23 Thomas Combezou.
Sale Sharks: 15 Rob Miller, 14 Tom Brady, 13 Will Addison, 12 Mark Jennings, 11 Mark Cueto, 10 Danny Cipriani, 9 Cillian Willis, 8 Mark Easter, 7 David Seymour (capt), 6 James Gaskell, 5 Kearnan Myall, 4 Fraser McKenzie, 3 Tony Buckley, 2 Joe Ward, 1 Eifion Lewis-Roberts.
Replacements: 16 Tommy Taylor, 17 Ross Harrison, 18 Vadim Cobilas, 19 Richie Vernon, 20 Andy Powell, 21 Nathan Fowles, 22 Nick Macleod, 23 Johnny Leota.
"We gained a lot of confidence from the last 25 minutes last weekend, but not many teams go to France and win against the top six, no matter how well you've been playing.
"It's a hugely challenging task for us, but one to which we're looking forward. We need to maintain that level of performance and accuracy for longer.
"There was a 15-minute spell against Cardiff where we conceded three tries last Sunday, which nearly ruined a lot of things for us. We're looking to push on and be better this weekend."
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Read the thoughts and opinions of Stuart Barnes with skysports.com