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Injury-hit Ospreys face the daunting task of travelling to four-time Heineken Cup winners Toulouse on Saturday.
The reigning Pro12 champions will want to bounce back from their disappointing defeat to Leicester Tigers at Welford Road but have lost both their previous games to Toulouse, who top Pool Two with two wins out of two.
The Welsh side have won only one of their 11 games in France in the Heineken Cup, against Bourgoin back in 2008, while Toulouse have lost just one of 15 home games against Welsh opposition in the competition, losing to Llanelli Scarlets back in 2006.
The Ospreys' assignment task looks even more difficult with a host of Welsh internationals, like skipper Alun Wyn Jones, props Adam Jones and Aaron Jarvis, all ruled out with injury.
Campbell Johnstone makes his Ospreys debut, while Ross Jones, Scott Baldwin and James King make their Heineken Cup debuts, as will Matthew Dwyer, Dmitri Arhip and Lloyd Peers if they come off the bench.
Toulouse: 15 Yoann Huget, 14 Maxime Medard, 13 Yann David, 12 Florian Fritz, 11 Vincent Clerc, 10 Luke McAlister, 9 Luke Burgess, 8 Louis Picamoles, 7 Yannick Nyanga, 6 Jean Bouilhou, 5 Patricio Albacete, 4 Romain Millo-Chluski, 3 Census Johnston, 2 Gary Botha, 1 Gurthro Steenkamp.
Replacements: 16 Jean-Marc Doussain, 17 Gael Fickou, 18 Gregory Lamboley, 19 Yoann Maestri, 20 Edwin Maka, 21 Yohan Montes, 22 Jean-Baptiste Poux, 23 Christopher Tolofua.
Ospreys: 15 Richard Fussell, 14 Ross Jones, 13 Andrew Bishop, 12 Ashley Beck, 11 Eli Walker, 10 Dan Biggar, 9 Kahn Fotuali'i (c), 8 Joe Bearman, 7 Justin Tipuric, 6 Ryan Jones, 5 James King, 4 Ian Gough, 3 Campbell Johnstone, 2 Scott Baldwin, 1 Duncan Jones.
Replacements: 16 Matthew Dwyer, 17 Ryan Bevington, 18 Dmitri Arhip, 19 Lloyd Peers, 20 Sam Lewis, 21 Rhys Webb, 22 Matthew Morgan, 23 Tom Isaacs.
"To go and take on someone like Toulouse at their ground is one of the toughest asks in European rugby, particularly when we have such a long injury list. We are up against one of the strongest squads in the competition with a budget that you can't compare to ours, and we know that we are going to have to be at our very best if we hope to get anything out of the game whatsoever."
Don't miss any live and exclusive rugby union coverage this festive season. Click hereto visit Sky Sports' Festive Calendar
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|Friday 6th December|
|20:00||Castres vs Ospreys|
|20:00||Cardiff Blues vs Glasgow|
|Saturday 7th December|
|18:00||Northampton vs Leinster|
|13:35||Exeter vs Toulon|
|13:35||Zebre vs Saracens|
|13:35||Clermont Auvergne vs Scarlets|
|15:40||Racing Metro 92 vs Harlequins|
|18:00||Ulster vs Benetton Treviso|
|Sunday 8th December|
|15:00||Toulouse vs Connacht|
|15:00||Leicester vs Montpellier|
|12:45||Munster vs Perpignan|
|13:00||Edinburgh vs Gloucester|
|Friday 13th December|
|20:00||Ospreys vs Castres|
|20:00||Glasgow vs Cardiff Blues|
|Saturday 14th December|
|18:00||Leinster vs Northampton|
|13:35||Toulon vs Exeter|
|15:00||Saracens vs Zebre|
|18:00||Connacht vs Toulouse|
|15:40||Scarlets vs Clermont Auvergne|
|13:35||Benetton Treviso vs Ulster|
|15:40||Perpignan vs Munster|
|Sunday 15th December|
|12:45||Harlequins vs Racing Metro 92|
|15:00||Montpellier vs Leicester|
|15:00||Gloucester vs Edinburgh|
|Saturday 11th January|
|TBC||Ospreys vs Northampton|
|Sunday 20th October|
|Clermont Auvergne 23 - 16 Harlequins|
|Glasgow 20 - 16 Exeter|
|Northampton 27 - 16 Ospreys|
|Perpignan 31 - 14 Edinburgh|
|Saturday 19th October|
|Scarlets 26 - 26 Racing Metro 92|
|Munster 26 - 10 Gloucester|
|Leinster 19 - 7 Castres|
|Montpellier 8 - 25 Ulster|
|Cardiff Blues 19 - 15 Toulon|
|Zebre 6 - 33 Connacht|
|Friday 18th October|
|Leicester 34 - 3 Benetton Treviso|
|Saracens 16 - 17 Toulouse|
Read the thoughts and opinions of Stuart Barnes with skysports.com