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Scarlets welcome back George North and Jonathan Davies as they take on unbeaten Pool 5 rivals Clermont Auvergne on Saturday.
The Welsh side have yet to rcord a win in Europe this season, including going down to a 49-16 loss against their next opponents at the start of the competition.
Head coach Simon Easterby has opted to move Rob McCusker to number eight with Sioni Timani starting at blindside flanker, whilst Johan Snyman comes into the second row.
Exciting prospect Samson Lee starts at tighthead prop, meaning South African Jacobie Adriaanse drops to the bench.
Clermont, meanwhile, know a win in Wales would make certain of a home quarter-final. They have yet to taste defeat in the group stages, including a 46-3 thrashing of Exeter last time out.
The Heineken Cup favourites have made no less than eight changes from the side that put the Chiefs to the sword, including handing a start to Wales international Lee Byrne at full-back.
Julien Malzieu comes in on the right wing with Benson Stanley partnering captain Aurelien Rougerie in the centres. David Skrela is the other change in the backs, coming in at fly-half for Brock James.
In the pack, Raphael Chaume starts in place of Thomas Domingo, with Alexandre Lapandry and Elvis Vermeulen joining Julien Bonnaire into the back-row.
Clermont reached last season's semi-finals only to be knocked out by eventual winners Leinster, who are still hopeful of making it out of the same pool this year.
Scarlets: 15 Liam Williams, 14 George North, 13 Jonathan Davies, 12 Adam Warren, 11 Kristian Phillips, 10 Aled Thomas, 9 Tavis Knoyle, 8 Rob McCusker, 7 Josh Turnbull, 6 Sione Timani, 5 Johan Snyman, 4 George Earle, 3 Samson Lee, 2 Ken Owens, 1 Phil John.
Replacements: 16 Matthew Rees, 17 Rhodri Jones, 18 Jacobie Adriaanse, 19 Richard Kelly, 20 Aaron Shingler, 21 Gareth Davies, 22 Gareth Maule, 23 Andy Fenby.
Clermont Auvergne: 15 Lee Byrne, 14 Julien Malzieu, 13 Aurélien Rougerie (c), 12 Benson Stanley, 11 Napolioni Nalaga, 10 David Skrela, 9 Morgan Parra, 8 Elvis Vermeulen, 7 Alexandre Lapandry, 6 Julien Bonnaire, 5 Nathan Hines, 4 Jamie Cudmore, 3 Davit Zirakashvili, 2 Benjamin Kayser, 1 Raphael Chaume.
Replacements: 16 Ti'i Paulo, 17 Vincent Debaty, 18 Daniel Kotze, 19 Julien Pierre, 20 Damien Chouly, 21 Ludovic Radoslavjevic , 22 Kevin Senio, 23 Regan King.
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|Friday 13th December|
|20:00||Ospreys vs Castres|
|20:00||Glasgow vs Cardiff Blues|
|Saturday 14th December|
|18:00||Leinster vs Northampton|
|13:35||Toulon vs Exeter|
|15:00||Saracens vs Zebre|
|18:00||Connacht vs Toulouse|
|15:40||Scarlets vs Clermont Auvergne|
|13:35||Benetton Treviso vs Ulster|
|15:40||Perpignan vs Munster|
|Sunday 15th December|
|12:45||Harlequins vs Racing Metro 92|
|15:00||Montpellier vs Leicester|
|15:00||Gloucester vs Edinburgh|
|Saturday 11th January|
|TBC||Ospreys vs Northampton|
|TBC||Castres vs Leinster|
|TBC||Exeter vs Glasgow|
|TBC||Toulon vs Cardiff Blues|
|TBC||Toulouse vs Saracens|
|TBC||Connacht vs Zebre|
|TBC||Harlequins vs Clermont Auvergne|
|TBC||Racing Metro 92 vs Scarlets|
|TBC||Ulster vs Montpellier|
|TBC||Benetton Treviso vs Leicester|
|TBC||Edinburgh vs Perpignan|
|TBC||Gloucester vs Munster|
|Saturday 18th January|
|TBC||Leinster vs Ospreys|
|Sunday 8th December|
|Toulouse 14 - 16 Connacht|
|Leicester 41 - 32 Montpellier|
|Edinburgh 12 - 23 Gloucester|
|Munster 36 - 8 Perpignan|
|Saturday 7th December|
|Northampton 7 - 40 Leinster|
|Ulster 48 - 0 Benetton Treviso|
|Racing Metro 92 8 - 32 Harlequins|
|Clermont Auvergne 32 - 11 Scarlets|
|Zebre 10 - 39 Saracens|
|Exeter 9 - 14 Toulon|
|Friday 6th December|
|Castres 15 - 9 Ospreys|
|Cardiff Blues 29 - 20 Glasgow|
Read the thoughts and opinions of Stuart Barnes with skysports.com