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Bath have named club captain Stuart Hooper in their side to face Bath in Friday's Aviva Premiership clash.
Hooper will partner Dave Attwood in the second row, with Josh Ovens set to make his first Premiership start of the season on the blindside flank.
Former Army back Semesa Rokoduguni will also appear in the competition for the first time, partnering Matt Banahan in the centres, with Kyle Eastmond returning to the wing.
Michael Claassens and Stephen Donald will also return to renew their half-back partnership.
Harlequins have made seven changes to the starting line-up that beat Bath in the LV=Cup - with New Zealand international Nick Evans returning to action.
Evans, fit again after an ankle problem, will team up with scrum-half Karl Dickson.
Ugo Monye, George Robson and Jordan Turner-Hall are all free to start after being released by England, while Luke Wallace and Tom Guest join Nick Evans in the back-row.
On the bench, Jordan Burns is in line to make his first senior appearance for the club.
Bath: 15 Nick Abendanon, 14 Kyle Eastmond, 13 Semesa Rokoduguni, 12 Matt Banahan, 11 Tom Biggs, 10 Stephen Donald, 9 Michael Claassens, 1 Charlie Beech, 2 Lee Mears, 3 Anthony Perenise, 4 Stuart Hooper (c), 5 Dave Attwood, 6 Josh Ovens, 7 Guy Mercer, 8 Simon Taylor.
Replacements: 16 Brett Sharman, 17 Alan Cotter, 18 Kane Palma-Newport, 19 Dominic Day, 20 Ryan Caldwell, 21 Will Skuse, 22 Mark McMillan, 23 Jack Cuthbert
Harlequins: 15 Tom Williams, 14 Ugo Monye, 13 Matt Hopper, 12 Jordan Turner-Hall, 11 Sam Smith, 10 Nick Evans, 9 Karl Dickson, 1 Mark Lambert, 2 Joe Gray, 3 Will Collier, 4 Olly Kohn, 5 George Robson, 6 Tom Guest, 7 Luke Wallace, 8 Nick Easter (c).
Replacements: 16 Rob Buchanan, 17 Darryl Marfo, 18 Kyle Sinckler, 19 Pete Browne, 20 Joe Trayfoot, 21 Jordan Burns, 22 Rory Clegg, 23 Seb Stegmann
"Having lost out to Harlequins in the LV= Cup last week, this is our chance to learn from the mistakes we made and improve on them at the Rec.
"To test ourselves against the likes of Quins is massive for us, and it's probably the biggest match of our season so far - it's a chance for us to prove we can compete with the best."
|Click here for more betting|
|Saturday 25th May|
|15:00||Leicester vs Northampton|
|Sunday 12th May|
|Saracens 13 - 27 Northampton|
|Saturday 11th May|
|Leicester 33 - 16 Harlequins|
|Saturday 4th May|
|Leicester 32 - 20 London Irish|
|London Welsh 33 - 22 Worcester|
|Harlequins 22 - 19 Northampton|
|Sale 21 - 20 Wasps|
|Exeter 40 - 39 Gloucester|
|Saracens 23 - 14 Bath|
|Sunday 21st April|
|Wasps 24 - 37 Exeter|
|Saturday 20th April|
|Northampton 47 - 7 Sale|
|Gloucester 28 - 23 Saracens|
|London Irish 47 - 28 London Welsh|
|Worcester 26 - 42 Harlequins|
|Bath 27 - 26 Leicester|
|Sunday 14th April|
|Leicester 35 - 16 Wasps|
|Saracens 47 - 17 Worcester|
|London Welsh 14 - 31 Northampton|
|Saturday 13th April|
|Exeter 27 - 6 London Irish|
|Harlequins 23 - 9 Bath|
|Friday 12th April|
|Sale 32 - 9 Gloucester|
Read the thoughts and opinions of Stuart Barnes with skysports.com