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The Cheetahs have not beaten the Highlanders since 2006 and things don't get much easier when they head to Rugby Park Stadium on Saturday.
The Highlanders had the bye in the last round and head coach Jamie Joseph is expected to have Andrew Hore, Colin Slade and Brad Thorn all back for the home side.
They have lost No 8 Nasi Manu with a major foot injury for the clash but All Blacks duo Colin Slade (leg) and skipper Andrew Hore (suspension) are set to return.
Meanwhile, Cheetahs head coach Naka Drotske has named Heinrich Brussow in his team following last week's 45-3 defeat by the champion Chiefs.
The flanker has been named on the bench for the first time this season after recovering from a shoulder operation and replaces replaces Boom Prinsloo on the replacements bench.
He could well be eased back in during the second half and his return is the only change to the team that lost to the Chiefs last time out.
Highlanders: 15 Ben Smith, 14 Kade Poko, 13 Phil Burleigh, 12 Ma'a Nonu, 11 Hosea Gear, 10 Lima Sopoaga, 9 Aaron Smith, 8 Jake Paringatai, 7 John Hardie, 6 Joe Wheeler, 5 Josh Berkhuis, 4 Brad Thorn, 3 Ma'afu Fia, 2 Andrew Hore (capt), 1 Toy Woodcock
Replacements: 16 Brayden Mitchell, 17 Chris King, 18 Jarrad Hoeata, 19 Tim Boys, 20 Fumiaki Tanaka, 21 Colin Slade, 22 Shaun Treeby
Cheetahs: 15 Hennie Daniller, 14 Willie le Roux, 13 Johann Sadie, 12 Robert Ebersohn, 11 Raymond Rhule, 10 Johan Goosen, 9 Sarel Pretorius, 8 Philip van der Walt, 7 Pieter Labuschagne, 6 Frans Viljoen, 5 Francois Uys, 4 Lodewyk de Jager, 3 Lourens Adriaanse, 2 Adriaan Strauss (capt), 1 Trevor Nyakane
Replacements: 16 Ryno Barnes, 17 Coenie Oosthuizen, 18 Rynhard Landman, 19 Heinrich Brüssow, 20 Piet van Zyl, 21 Riaan Smith, 22 Ryno Benjamin
"He (fly-half Johan Goosen) gets worried if he misses one kick. I told him to be calm and not put too much pressure on himself.
"Johan works hard enough at his kicking. I'm sure we'll see him kick like we know he can within a week or two. Last year he was successful with something like 86 per cent or 87 per cent of his kicks."
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|Saturday 25th May|
|10:40||Western Force vs Highlanders|
|16:00||Southern Kings vs Cheetahs|
|16:05||Stormers vs Reds|
|18:10||Sharks vs Bulls|
|Friday 31st May|
|08:35||Crusaders vs Waratahs|
|10:40||Brumbies vs Hurricanes|
|Saturday 1st June|
|08:35||Highlanders vs Blues|
|10:40||Reds vs Melbourne Rebels|
|16:05||Stormers vs Southern Kings|
|18:10||Cheetahs vs Bulls|
|Friday 7th June|
|10:40||Brumbies vs Melbourne Rebels|
|Sunday 9th June|
|07:05||Western Force vs Waratahs|
|Friday 28th June|
|08:35||Chiefs vs Hurricanes|
|Saturday 29th June|
|08:35||Highlanders vs Crusaders|
|14:00||Sharks vs Blues|
|16:05||Bulls vs Southern Kings|
|18:10||Stormers vs Cheetahs|
|Friday 5th July|
|08:35||Crusaders vs Chiefs|
|Saturday 6th July|
|08:35||Hurricanes vs Highlanders|
|14:00||Cheetahs vs Blues|
|16:05||Southern Kings vs Stormers|
|18:10||Bulls vs Sharks|
|Friday 12th July|
|08:35||Crusaders vs Hurricanes|
|10:40||Melbourne Rebels vs Highlanders|
|Saturday 13th July|
|08:35||Blues vs Chiefs|
|Saturday 25th May|
|Blues 13 - 20 Brumbies|
|Friday 24th May|
|Melbourne Rebels 24 - 22 Waratahs|
|Chiefs 28 - 19 Crusaders|
|Saturday 18th May|
|Cheetahs 27 - 13 Reds|
|Bulls 35 - 18 Highlanders|
|Waratahs 28 - 22 Brumbies|
|Crusaders 23 - 3 Blues|
|Friday 17th May|
|Western Force 13 - 23 Sharks|
|Melbourne Rebels 30 - 21 Stormers|
|Hurricanes 12 - 17 Chiefs|
|Saturday 11th May|
|Southern Kings 34 - 27 Highlanders|
|Waratahs 21 - 15 Stormers|
|Blues 36 - 32 Melbourne Rebels|
|Friday 10th May|
|Cheetahs 34 - 39 Hurricanes|
|Reds 32 - 17 Sharks|
|Chiefs 22 - 21 Western Force|
|Sunday 5th May|
|Brumbies 23 - 30 Crusaders|
|Saturday 4th May|
|Bulls 48 - 14 Hurricanes|
|Southern Kings 10 - 72 Waratahs|
|Western Force 11 - 11 Reds|
|Highlanders 25 - 22 Sharks|
|Friday 3rd May|
|Melbourne Rebels 33 - 39 Chiefs|
|Blues 18 - 17 Stormers|
|Sunday 28th April|
|Crusaders 30 - 26 Melbourne Rebels|
|Saturday 27th April|
|Cheetahs 26 - 12 Southern Kings|
Read the thoughts and opinions of Stuart Barnes with skysports.com