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The Reds will be without captain James Horwill for Fridays Super Rugby encounter against the Sharks at Suncorp Stadium.
Horwill has been rested as part of his recovery from the a jaw injury, with Will Genia leading the side on his absence.
The Reds have made four changes to their line-up following the 11-11 draw with the Force.
Ed O'Donoghue and James Slipper come into the pack, while Rod Davies and Chris Feauai-Sautia start in the backs.
The Sharks have made three changes of personnel to the starting line-up that lost to the Highlanders last time out.
Piet Lindeque, Jean Deysel and JC Janse van Rensburg all start, with coach John Plumtree making some positional alterations.
JP Pietersen moves across to outside centre, Wiehahn Herbst starts at tighthead, Keegan Daniel returns to No 8 and Marcell Coetzee handed the No 6 jersey.
Monde Hadebe could also make his Super Rugby debut having been named on the bench, where he is joined by Springboks flanker Willem Alberts.
Reds: 15 Jono Lance, 14 Rod Davies, 13 Chris Feauai-Sautia, 12 Anthony Faingaa, 11 Digby Ioane, 10 Quade Cooper, 9 Will Genia (c), 1 Greg Holmes, 2 Saia Faingaa, 3 James Slipper, 4 Rob Simmons, 5 Ed O'Donoghue, 6 Eddie Quirk, 7 Liam Gill, 8 Jake Schatz.
Replacements: 16 James Hanson, 17 Albert Anae, 18 Adam Wallace-Harrison, 19 Beau Robinson, 20 Jarrad Butler, 21 Ben Lucas, 22 Ben Tapuai
Sharks: 15 Riaan Viljoen, 14 Piet Lindeque, 13 JP Pietersen, 12 Meyer Bosman, 11 Lwazi Mvovo, 10 Patrick Lambie, 9 Charl McLeod, 8 Keegan Daniel (c), 7 Jean Deysel, 6 Marcell Coetzee, 5 Franco van der Merwe, 4 Pieter-Steph du Toit, 3 Wiehahn Herbst, 2 Kyle Cooper, 1 JC Janse van Rensburg.
Replacements: 16 Monde Hadebe, 17 Jannie du Plessis, 18 Anton Bresler, 19 Derick Minnie, 20 Willem Alberts, 21 Tian Meyer, 22 Odwa Ndungane.
"The Sharks are battling a few injuries but they are still stacked with talent across the park, including having a number of Springboks on their bench.
"It's going to be a huge game and we're also cognisant of the importance of getting an outcome before we get on the plane to South Africa."
"We've sent four to five guys home already and it's only halfway through the tour. We've had to change personnel, we've had to play players out of position, it's not great. But right now the focus is solely on getting a team prepared for the weekend."
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|Saturday 15th February|
|15:05||Cheetahs vs Lions|
|17:10||Sharks vs Bulls|
|Friday 21st February|
|06:35||Crusaders vs Chiefs|
|17:10||Cheetahs vs Bulls|
|Saturday 22nd February|
|06:35||Highlanders vs Blues|
|08:40||Brumbies vs Reds|
|15:05||Sharks vs Hurricanes|
|17:10||Lions vs Stormers|
|Sunday 23rd February|
|05:05||Waratahs vs Western Force|
|Friday 28th February|
|06:35||Blues vs Crusaders|
|08:40||Melbourne Rebels vs Cheetahs|
|17:10||Stormers vs Hurricanes|
|Saturday 1st March|
|06:35||Chiefs vs Highlanders|
|08:40||Waratahs vs Reds|
|15:05||Western Force vs Brumbies|
|Friday 7th March|
|06:35||Hurricanes vs Brumbies|
|08:40||Reds vs Cheetahs|
|Saturday 8th March|
|06:35||Crusaders vs Stormers|
|08:40||Western Force vs Melbourne Rebels|
|15:05||Bulls vs Blues|
|17:10||Sharks vs Lions|
|Friday 14th March|
|06:35||Chiefs vs Stormers|
|08:40||Melbourne Rebels vs Crusaders|
|Saturday 15th March|
|06:35||Highlanders vs Western Force|
|08:40||Brumbies vs Waratahs|
Read the thoughts and opinions of Stuart Barnes with skysports.com