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Ospreys are without 15 players for their game against Edinburgh in the RaboDirect PRO12 on Friday night due to international duty with Wales senior and U20 squads.
Joe Bearman and Ross Jones have added a further headache to coach Steve Tandy as suspension means the pair are also both unavailable for selection for the game at the Liberty Stadium.
Tandy has named Sam Williams and Arthur Ellis on the bench for Friday's game with both hoping to make a debut, Ospreys will hope to reverse their recent form and begin to move up the table.
Edinburgh coach Michael Bradley is looking to youth, fielding no less than nine players aged 23 or under in the visitors' match-day squad.
A combination of injuries and international call-ups have handed highly-rated flanker Hamish Watson, 21, his first start for the club after seven appearances off the bench.
Dougie Fife, 22, Stuart McInally, 22 and Greig Tonks, 23, retain their increasingly ever-present places at wing, back row and full-back respectively - as well as 20-year-old Harry Leonard being rewarded with a start.
Ospreys: 15 Richard Fussell, 14 Tom Habberfield, 13 Tom Isaacs, 12 Jonathan Spratt, 11 Kahn Fotuali'I (c), 10 Matthew Morgan, 9 Rhys Webb, 1 Ryan Bevington, 2 Scott Baldwin, 3 Cai Griffiths, 4 Lloyd Peers, 5 Jonathan Thomas, 6 James King, 7 Sam Lewis, 8 Morgan Allen
Replacements 16 Matthew Dwyer, 17 Marc Thomas, 18 Dmitri Arhip, 19 Sam Williams, 20 George Stowers, 21 Arthur Ellis, 22 Ashley Beck, 23 Tom Grabham
Edinburgh: 15 Greig Tonks, 14 Dougie Fife, 13 Nick De Luca, 12 Ben Atiga, 11 Lee Jones, 10 Harry Leonard, 9 Richie Rees, 8 Netani Talei, 7 Hamish Watson, 6 Stuart McInally, 5 Sean Cox (capt), 4 Perry Parker, 3 Willem Nel, 2 Steven Lawrie, 1 John Yapp
Replacements: 16 Andy Titterrell, 17 Allan Jacobsen, 18 Alex Allan, 19 Robert McAlpine, 20 Chris Leck, 21 Piers Francis, 22 Ben Cairns, 23 Tom Brown.
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|Saturday 25th May|
|16:45||Ulster vs Leinster|
|Saturday 11th May|
|Leinster 17 - 15 Glasgow|
|Friday 10th May|
|Ulster 28 - 17 Scarlets|
|Friday 3rd May|
|Edinburgh 31 - 24 Newport Gwent D'gons|
|Connacht 3 - 20 Glasgow|
|Zebre 25 - 27 Munster|
|Scarlets 17 - 41 Benetton Treviso|
|Leinster 37 - 19 Ospreys|
|Ulster 37 - 13 Cardiff Blues|
|Friday 26th April|
|Benetton Treviso 23 - 23 Connacht|
|Sunday 21st April|
|Zebre 22 - 41 Leinster|
|Saturday 20th April|
|Scarlets 24 - 6 Cardiff Blues|
|Friday 19th April|
|Connacht 18 - 34 Ulster|
|Glasgow 35 - 17 Ospreys|
|Benetton Treviso 30 - 10 Edinburgh|
|Newport Gwent D'gons 30 - 24 Munster|
|Saturday 13th April|
|Ospreys 28 - 3 Benetton Treviso|
|Munster 16 - 22 Leinster|
|Cardiff Blues 28 - 13 Zebre|
|Friday 12th April|
|Edinburgh 24 - 32 Connacht|
|Ulster 31 - 5 Newport Gwent D'gons|
|Scarlets 29 - 6 Glasgow|
Read the thoughts and opinions of Stuart Barnes with skysports.com