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Ospreys are without 15 players for their game against Edinburgh in the RaboDirect PRO12 on Friday night due to international duty with Wales senior and U20 squads.
Joe Bearman and Ross Jones have added a further headache to coach Steve Tandy as suspension means the pair are also both unavailable for selection for the game at the Liberty Stadium.
Tandy has named Sam Williams and Arthur Ellis on the bench for Friday's game with both hoping to make a debut, Ospreys will hope to reverse their recent form and begin to move up the table.
Edinburgh coach Michael Bradley is looking to youth, fielding no less than nine players aged 23 or under in the visitors' match-day squad.
A combination of injuries and international call-ups have handed highly-rated flanker Hamish Watson, 21, his first start for the club after seven appearances off the bench.
Dougie Fife, 22, Stuart McInally, 22 and Greig Tonks, 23, retain their increasingly ever-present places at wing, back row and full-back respectively - as well as 20-year-old Harry Leonard being rewarded with a start.
Ospreys: 15 Richard Fussell, 14 Tom Habberfield, 13 Tom Isaacs, 12 Jonathan Spratt, 11 Kahn Fotuali'I (c), 10 Matthew Morgan, 9 Rhys Webb, 1 Ryan Bevington, 2 Scott Baldwin, 3 Cai Griffiths, 4 Lloyd Peers, 5 Jonathan Thomas, 6 James King, 7 Sam Lewis, 8 Morgan Allen
Replacements 16 Matthew Dwyer, 17 Marc Thomas, 18 Dmitri Arhip, 19 Sam Williams, 20 George Stowers, 21 Arthur Ellis, 22 Ashley Beck, 23 Tom Grabham
Edinburgh: 15 Greig Tonks, 14 Dougie Fife, 13 Nick De Luca, 12 Ben Atiga, 11 Lee Jones, 10 Harry Leonard, 9 Richie Rees, 8 Netani Talei, 7 Hamish Watson, 6 Stuart McInally, 5 Sean Cox (capt), 4 Perry Parker, 3 Willem Nel, 2 Steven Lawrie, 1 John Yapp
Replacements: 16 Andy Titterrell, 17 Allan Jacobsen, 18 Alex Allan, 19 Robert McAlpine, 20 Chris Leck, 21 Piers Francis, 22 Ben Cairns, 23 Tom Brown.
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|Saturday 26th April|
|19:05||Glasgow vs Edinburgh|
|Thursday 1st May|
|17:00||Zebre vs Ospreys|
|Friday 2nd May|
|19:00||Benetton Treviso vs Glasgow|
|19:05||Scarlets vs Newport Gwent D'gons|
|19:30||Ulster vs Leinster|
|Saturday 3rd May|
|17:00||Edinburgh vs Munster|
|17:00||Connacht vs Cardiff Blues|
|Saturday 10th May|
|18:30||Leinster vs Edinburgh|
|18:30||Scarlets vs Cardiff Blues|
|18:30||Ospreys vs Connacht|
|18:30||Newport Gwent D'gons vs Benetton Treviso|
|18:30||Munster vs Ulster|
|18:30||Glasgow vs Zebre|
|Sunday 20th April|
|Newport Gwent D'gons 10 - 20 Ospreys|
|Cardiff Blues 17 - 13 Scarlets|
|Saturday 19th April|
|Connacht 23 - 32 Munster|
|Zebre 26 - 13 Edinburgh|
|Friday 18th April|
|Glasgow 27 - 9 Ulster|
|Leinster 62 - 7 Benetton Treviso|
|Saturday 12th April|
|Munster 5 - 22 Glasgow|
|Scarlets 27 - 20 Zebre|
|Benetton Treviso 45 - 27 Newport Gwent D'gons|
|Friday 11th April|
|Edinburgh 22 - 29 Cardiff Blues|
|Ulster 58 - 12 Connacht|
|Ospreys 25 - 19 Leinster|
|Friday 4th April|
|Glasgow 29 - 10 Benetton Treviso|
|Thursday 3rd April|
|Newport Gwent D'gons 19 - 23 Edinburgh|
|Sunday 30th March|
|Scarlets 32 - 30 Connacht|
|Saturday 29th March|
|Leinster 22 - 18 Munster|
|Cardiff Blues 28 - 23 Ulster|
|Benetton Treviso 20 - 16 Edinburgh|
|Zebre 25 - 25 Newport Gwent D'gons|
|Friday 28th March|
|Glasgow 11 - 9 Ospreys|
|Sunday 23rd March|
|Newport Gwent D'gons 8 - 24 Connacht|
|Saturday 22nd March|
|Munster 14 - 3 Benetton Treviso|
|Glasgow 14 - 6 Scarlets|
|Friday 21st March|
|Edinburgh 3 - 9 Ulster|
|Leinster 27 - 0 Zebre|
Read the thoughts and opinions of Stuart Barnes with skysports.com