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Sale will be looking to upset the odds and end Harlequins' hopes of a treble when the two Aviva Premiership sides meet in Sunday's LV= Cup Final.
The Sharks have belied their poor form in league action to get this far in the Anglo-Welsh competition, including seeing off table-topping Saracens in the semi-finals last time out.
If they can overcome another high-flying opponent at Sixways Sale will not only lift their first trophy since 2006 but also automatically secure a place in next season's Heineken Cup.
In total they have used 45 players so far; only Tony Buckley, Danny Cipriani, Ross Harrison and Tommy Taylor have featured in every cup game.
Buckley and fellow prop Al Dickinson are drafted in after neither started the game with Sarries. They take the places of Henry Thomas and Ross Harrison, who are both amongst the list of replacements this time around.
In the backs, Nick Macleod switches from centre to full-back in place of Cameron Shepherd, meaning Jonny Leota moves from outside to inside centre and Will Addison comes into the starting XV in the No 13 jersey.
Nathan Fowles gets the nod at scrum-half with Dwayne Peel joining former England international Mark Cueto on the bench.
As for Harlequins, they have selected the same line-up that defeated Bath 31-23 in the first semi-final at the Twickenham Stoop last weekend.
There is, though, one change in the matchday 22; James Johnston takes the place of Kyle Sinckler, who is away with the England U20s in Wales, on the bench.
The capital club have come out on top in the last six meetings between the two teams in all competitions.
Harlequins: 15 Ross Chisholm, 14 Tom Williams, 13 George Lowe, 12 Tom Casson, 11 Sam Smith, 10 Ben Botica, 9 Karl Dickson, 8 Tom Guest, 7 Luke Wallace (capt), 6 Maurie Fa'asavalu, 5 Charlie Matthews, 4 Sam Twomey, 3 Will Collier, 2 Rob Buchanan, 1 Mark Lambert.
Replacements: 16 Dave Ward, 17 Darryl Marfo, 18 James Johnston, 19 Pete Browne, 20 Joe Trayfoot, 21 Jordan Burns, 22 Rory Clegg, 23 Charlie Walker.
Sale Sharks: 15 Nick Macleod, 14 Tom Brady, 13 Will Addison, 12 Johnny Leota, 11 Charlie Ingall, 10 Danny Cipriani, 9 Nathan Fowles, 8 Andy Powell, 7 David Seymour (capt), 6 James Gaskell, 5 Tom Holmes, 4 Fraser McKenzie, 3 Tony Buckley, 2 Marc Jones, 1 Al Dickinson.
Replacements: 16 Tommy Taylor, 17 Ross Harrison, 18 Henry Thomas, 19 Andrei Ostrikov, 20 Daniel Braid, 21 Dwayne Peel, 22 Sammy Tuitipou, 23 Mark Cueto.
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