Guide to this winter's Australia v England series
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Gloucester director of rugby Nigel Davies has made five changes to his starting XV for Friday's clash with defending Aviva Premiership champions Harlequins.
There is just one switch in the three-quarters as Henry Trinder comes in for Mike Tindall.
Up front, Koree Britton will make his first league start at hooker, while Lua Lokotui returns to form a second-row alliance with Jim Hamilton.
In the back row, Tom Savage and Akapusi Qera resume their usual positions as blindside and openside flanker respectively.
Davies acknowledged that his team will have to be at their best to take something from Quins, stating: "It's all about how we perform on Friday night. It's a big game, against a tough opponent who have been trailblazing over the last two or three years in terms of their performances and results. So, it'll be a big test for us."
With their trip to Kingsholm coming just five days after their last outing, Harlequins have made six changes to the side that lost to Saracens last Sunday.
In the backline, Ross Chisholm comes in for Ugo Monye, while George Lowe and Tom Casson combine in the centres in place of Jordan Turner-Hall and Matt Hopper.
In the pack, Rob Buchanan is named at hooker with Olly Kohn returning from a hamstring injury to start in the second row.
With Chris Robshaw being rested for this fixture, Luke Wallace joins Tom Guest and Nick Easter, who captains the team, in the back-row.
Gloucester: 15 Rob Cook, 14 Charlie Sharples, 13 Henry Trinder, 12 Billy Twelvetrees, 11 Jonny May, 10 Freddie Burns, 9 Dan Robson, 8 Sione Kalamafoni, 7 Akapusi Qera, 6 Tom Savage, 5 Jim Hamilton (c), 4 Lua Lokotui, 3 Shaun Knight, 2 Koree Britton, 1 Dan Murphy
Replacements: 16 Huia Edmonds, 17 Nick Wood, 18 Dario Chistolini, 19 Will James, 20 Andy Hazell, 21 Dave Lewis, 22 Mike Tindall, 23 Martyn Thomas.
Harlequins: 15 Mike Brown, 14 Ross Chisholm, 13 George Lowe, 12 Tom Casson, 11 Sam Smith, 10 Nick Evans, 9 Danny Care, 8 Nick Easter (c), 7 Luke Wallace, 6 Tom Guest, 5 George Robson, 4 Olly Kohn, 3 James Johnston, 2 Rob Buchanan, 1 Joe Marler
Replacements: 16 Joe Gray, 17 Mark Lambert, 18 Will Collier, 19 Charlie Matthews, 20 Joe Trayfoot, 21 Karl Dickson, 22 Ben Botica, 23 Matt Hopper
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|Friday 20th December|
|20:00||Sale Sharks vs London Irish|
|Saturday 21st December|
|15:00||Exeter vs Newcastle|
|15:00||Bath vs Harlequins|
|15:00||Wasps vs Northampton|
|15:00||Saracens vs Leicester|
|Friday 27th December|
|TBC||Newcastle vs Wasps|
|Saturday 28th December|
|15:00||Northampton vs Bath|
|15:00||Worcester vs Saracens|
|15:00||Harlequins vs Exeter|
|15:00||Leicester vs Sale Sharks|
|Friday 3rd January|
|19:45||Newcastle vs Sale Sharks|
|Saturday 4th January|
|15:00||London Irish vs Worcester|
|15:00||Gloucester vs Saracens|
|15:00||Leicester vs Bath|
|Sunday 5th January|
|15:00||Wasps vs Exeter|
|Friday 7th February|
|19:45||Worcester vs Leicester|
|20:00||Sale Sharks vs Gloucester|
|Saturday 8th February|
|15:00||Harlequins vs Wasps|
|15:00||Bath vs Newcastle|
|15:00||Exeter vs Northampton|
|Sunday 9th February|
|15:00||Saracens vs London Irish|
|Friday 14th February|
|20:00||Sale Sharks vs Saracens|
|Saturday 15th February|
|15:00||Wasps vs London Irish|
|15:00||Northampton vs Worcester|
|15:00||Leicester vs Gloucester|
|Sunday 1st December|
|Newcastle 9 - 35 Harlequins|
|Saturday 30th November|
|Bath 21 - 16 Exeter|
|Worcester 10 - 33 Northampton|
|London Irish 12 - 19 Wasps|
|Saracens 24 - 19 Sale Sharks|
|Friday 29th November|
|Gloucester 17 - 22 Leicester|
|Sunday 24th November|
|Wasps 5 - 28 Bath|
|Saturday 23rd November|
|Northampton 18 - 0 Newcastle|
|Harlequins 27 - 19 Gloucester|
|Exeter 9 - 16 Saracens|
|Leicester 20 - 11 London Irish|
|Friday 22nd November|
|Sale Sharks 26 - 10 Worcester|
|Sunday 3rd November|
|Saracens 40 - 3 Newcastle|
|London Irish 14 - 19 Northampton|
|Saturday 2nd November|
|Leicester 16 - 23 Harlequins|
|Gloucester 30 - 32 Wasps|
|Friday 1st November|
|Sale Sharks 16 - 18 Exeter|
|Worcester 6 - 21 Bath|
|Sunday 27th October|
|Newcastle 13 - 11 London Irish|
|Wasps 22 - 12 Leicester|
|Saturday 26th October|
|Northampton 41 - 20 Saracens|
|Exeter 40 - 6 Worcester|
|Harlequins 24 - 3 Sale Sharks|
|Friday 25th October|
|Bath 15 - 13 Gloucester|
Read the thoughts and opinions of Stuart Barnes with skysports.com