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Sale will be looking to record just their second away win in the Aviva Premiership this season when they take on London Irish at the Madejski Stadium
Both sides have had their struggles in this campaign, though each recorded a victory last time out to ease themselves away from the bottom of the table.
Irish opened up a 10-point cushion over capital rivals London Welsh, who this week have failed to get a five-point deduction overturned, with a win over Worcester.
Director of rugby Brian Smith has stuck with the majority of the side that saw off the Warriors; the only change for the hosts sees winger Sailosi Tagicakibau return to the starting line-up.
Jebb Sinclair and Darren Allinson both come into the squad as replacements, with Topsy Ojo joining them on the bench having played the most matches in the squad this season.
Sale, meanwhile, have also kept faith in almost the entirety of the team that pipped Bath thanks to a late try from replacement Tom Brady.
The one alteration sees Andy Powell start at the back of the scrum with James Gaskell switching to the second row. Lock Kearnan Myall drops down to the bench.
London Irish: 15 Tom Homer, 14 Marland Yarde, 13 Guy Armitage, 12 Shane Geraghty, 11 Sailosi Tagicakibau, 10 Ian Humphreys, 9 Pat Phibbs, 8 Chris Hala'ufia, 7 Ofisa Treviranus, 6 Matt Garvey, 5 Bryn Evans, 4 George Skivington (c), 3 Halani Aulika, 2 David Paice, 1 Max Lahiff.
Replacements: 16 Scott Lawson, 17 Jerry Yanuyanutawa, 18 Leo Halavatau, 19 Jon Fisher, 20 Jebb Sinclair, 21 Topsy Ojo, 22 Jonathan Joseph, 23 Darren Allinson.
Sale Sharks: 15 Cameron Shepherd, 14 Charlie Amesbury, 13 Johnny Leota, 12 Sammy Tuitupou, 11 Mark Cueto, 10 Nick Macleod, 9 Dwayne Peel, 8 James Gaskell, 7 David Seymour (c), 6 Daniel Braid, 5 Andrei Ostrikov, 4 Kearnan Myall, 3 Henry Thomas, 2 Marc Jones, 1 Al Dickinson.
Replacements: 16 Tommy Taylor, 17 Ross Harrison, 18 Tony Buckley, 19 Tom Holmes, 20 Andy Powell, 21 Nathan Fowles, 22 Danny Cipriani, 23 Tom Brady.
"I was very pleased with the efforts of our entire squad last weekend.
"The forward pack fronted up and set a platform for the team to keep the scoreboard moving. On Sunday it is important we keep that same level of performance. Sale are currently playing well so we know it will be another challenge, but one we are ready for."
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|Friday 2nd May|
|19:45||Bath vs Northampton|
|Saturday 3rd May|
|15:00||Saracens vs Worcester|
|15:00||Wasps vs Newcastle|
|15:00||Gloucester vs London Irish|
|15:15||Sale vs Leicester|
|Sunday 4th May|
|14:00||Exeter vs Harlequins|
|Saturday 10th May|
|15:15||Newcastle vs Exeter|
|15:15||Northampton vs Wasps|
|15:15||Worcester vs Gloucester|
|15:15||Leicester vs Saracens|
|15:15||Harlequins vs Bath|
|15:15||London Irish vs Sale|
|Sunday 20th April|
|Newcastle 18 - 23 Saracens|
|Northampton 36 - 21 London Irish|
|Saturday 19th April|
|Wasps 38 - 30 Gloucester|
|Bath 32 - 20 Worcester|
|Exeter 12 - 55 Sale|
|Friday 18th April|
|Harlequins 24 - 20 Leicester|
|Sunday 13th April|
|London Irish 40 - 12 Newcastle|
|Saracens 28 - 24 Northampton|
|Saturday 12th April|
|Gloucester 17 - 18 Bath|
|Worcester 33 - 38 Exeter|
|Leicester 27 - 15 Wasps|
|Friday 11th April|
|Sale Sharks 12 - 27 Harlequins|
|Sunday 30th March|
|Newcastle 12 - 17 Worcester|
|Saturday 29th March|
|Northampton 16 - 22 Leicester|
|Wasps 20 - 32 Saracens|
|Exeter 13 - 14 Gloucester|
|Harlequins 23 - 9 London Irish|
|Friday 28th March|
|Bath 11 - 12 Sale Sharks|
|Sunday 23rd March|
|Leicester 45 - 15 Exeter|
|Saturday 22nd March|
|London Irish 23 - 44 Bath|
|Saracens 39 - 17 Harlequins|
|Gloucester 40 - 33 Newcastle|
|Sale Sharks 19 - 6 Northampton|
|Friday 21st March|
|Worcester 11 - 13 Wasps|
Read the thoughts and opinions of Stuart Barnes with skysports.com