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Third-placed Glasgow Warriors host fourth-placed Ospreys at Scotstoun Stadium on Friday as the race for the RaboDirect PRO12 play-offs hots up.
The game is sure to prove emotional for John Barclay, who will make his 150th appearance for the hosts.
The Scotland international, who has been with the club for nine years, will be leaving at the end of the season and could be playing in his final home game.
The Warriors back three is made up of Stuart Hogg at full-back, Sean Maitland on the right wing and Sean Lamont, who replaces DTH van der Merwe on the left.
Alex Dunbar comes in for Mark Bennett at outside centre and Graeme Morrison starts at inside centre.
Duncan Weir replaces Ruaridh Jackson at fly-half and Niko Matawalu comes in for Henry Pyrgos at scrum half.
In the forwards Ryan Grant starts at loose head in place of Gordon Reid, Pat MacArthur continues at hooker and Moray Low once again starts at tight head.
Captain Al Kellock combines with Tim Swinson in the second row and in the back row Rob Harley starts the game at blind-side, with Ryan Wilson dropping to the bench. Josh Strauss moves from blind-side to number eight, with Barclay once again starting at open-side.
The Warriors have Dougie Hall, Ofa Fainga'anuku, Ed Kalman, Tom Ryder, Ryan Wilson, Henry Pyrgos, Peter Horne and Van der Merwe in reserve.
For the Ospreys, there are two changes to the side which beat Treviso 28-3 last time to climb back into the play-off places.
Tom Isaacs starts in the centres ahead of Ashley Beck with Jonathan Spratt swapping to the No 12 jersey, while Duncan Jones is in for Ryan Bevington at prop.
Marc Thomas, Sam Lewis, Ross Jones come in on the bench.
Glasgow Warriors: 15 Stuart Hogg, 14 Sean Maitland, 13 Alex Dunbar, 12 Graeme Morrison, 11 Sean Lamont, 10 Duncan Weir, 9 Niko Matawalu, 8 Josh Strauss, 7 John Barclay, 6 Rob Harley, 5 Al Kellock (c), 4 Tim Swinson, 3 Moray Low, 2 Pat MacArthur, 1 Ryan Grant.
Replacements: 16 Dougie Hall, 17 Ofa Fainga'anuku, 18 Ed Kalman, 19 Tom Ryder, 20 Ryan Wilson, 21 Henry Pyrgos, 22 Peter Horne, 23 DTH van der Merwe.
Ospreys: 15 Richard Fussell, 14 Tom Habberfield, 13 Tom Isaacs, 12 Jonathan Spratt, 11 Ben John, 10 Dan Biggar, 9 Kahn Fotuali'i, 8 Joe Bearman, 7 Justin Tipuric, 6 James King, 5 Ian Evans, 4 Alun Wyn Jones (c), 3 Adam Jones, 2 Richard Hibbard, 1 Duncan Jones.
Replacements: 16 Scott Baldwin, 17 Marc Thomas, 18 Cai Griffiths, 19 Jonathan Thomas, 20 Sam Lewis, 21 Rhys Webb, 22 Matthew Morgan, 23 Ross Jones.
"It's a huge game for the club, even more so after our defeat to the Scarlets last week. We expect a reaction from our players tomorrow night. There have been a lot of memorable moments at Scotstoun this season and this has the potential to be another great game. We're really respectful of our opponents, they take a combative approach to every game, they challenge at the breakdown, have an excellent set piece and are ranked as the best defensive team in the competition."
"There are two tough games left, away to Glasgow and Leinster, and yes that's a tough run-in, but that's what we're about as Ospreys. If we are going to successfully defend our title then we've got to front up like proper champions, starting this Friday night in Scotland. We don't want to stumble over the line relying on others to slip up, if we are going into the play-offs we want to do it on merit while building some real momentum for the knock-out games."
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|Friday 20th December|
|19:05||Cardiff Blues vs Ospreys|
|19:05||Ulster vs Zebre|
|19:35||Glasgow vs Benetton Treviso|
|19:35||Edinburgh vs Leinster|
|Saturday 21st December|
|17:00||Connacht vs Newport Gwent D'gons|
|19:15||Munster vs Scarlets|
|Thursday 26th December|
|14:00||Scarlets vs Ospreys|
|15:05||Edinburgh vs Glasgow|
|17:00||Newport Gwent D'gons vs Cardiff Blues|
|Friday 27th December|
|19:15||Munster vs Connacht|
|Saturday 28th December|
|15:00||Benetton Treviso vs Zebre|
|18:45||Leinster vs Ulster|
|Wednesday 1st January|
|14:05||Cardiff Blues vs Newport Gwent D'gons|
|18:05||Glasgow vs Edinburgh|
|Friday 3rd January|
|19:05||Ulster vs Munster|
|Saturday 4th January|
|15:00||Zebre vs Benetton Treviso|
|15:00||Connacht vs Leinster|
|15:00||Ospreys vs Scarlets|
|Saturday 8th February|
|15:00||Benetton Treviso vs Scarlets|
|15:00||Newport Gwent D'gons vs Edinburgh|
|15:00||Glasgow vs Connacht|
|15:00||Zebre vs Leinster|
|15:00||Ulster vs Ospreys|
|15:00||Munster vs Cardiff Blues|
|Saturday 15th February|
|15:00||Connacht vs Edinburgh|
|Saturday 30th November|
|Leinster 36 - 19 Scarlets|
|Benetton Treviso 26 - 26 Cardiff Blues|
|Zebre 11 - 19 Ulster|
|Friday 29th November|
|Edinburgh 43 - 10 Connacht|
|Newport Gwent D'gons 14 - 18 Munster|
|Ospreys 16 - 28 Glasgow|
|Sunday 24th November|
|Benetton Treviso 20 - 21 Leinster|
|Saturday 23rd November|
|Cardiff Blues 10 - 31 Munster|
|Connacht 21 - 24 Scarlets|
|Ospreys 30 - 20 Zebre|
|Friday 22nd November|
|Glasgow 8 - 23 Newport Gwent D'gons|
|Ulster 41 - 17 Edinburgh|
|Saturday 2nd November|
|Munster 12 - 6 Ospreys|
|Scarlets 17 - 9 Ulster|
|Connacht 12 - 19 Glasgow|
|Cardiff Blues 17 - 13 Benetton Treviso|
|Friday 1st November|
|Edinburgh 25 - 23 Zebre|
|Newport Gwent D'gons 19 - 23 Leinster|
|Saturday 26th October|
|Leinster 16 - 13 Connacht|
|Friday 25th October|
|Edinburgh 20 - 13 Benetton Treviso|
|Glasgow 6 - 13 Munster|
|Ulster 39 - 21 Cardiff Blues|
|Ospreys 40 - 17 Newport Gwent D'gons|
|Zebre 16 - 16 Scarlets|
Read the thoughts and opinions of Stuart Barnes with skysports.com