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Ireland interim coach Les Kiss has named one debutant as he rings the changes ahead of Saturday's clash with Canada in Toronto.
Munster centre James Downey will make his international bow as Kiss makes seven changes to the side which beat the USA last weekend.
Andrew Trimble will earn his 50th cap on the wing in place of Simon Zebo who was called into the British and Irish Lions squad earlier in the week, while Felix Jones comes into the starting XV at full-back with Robbie Henshaw reduced to the bench.
With 11 players recovering from a stomach bug, Kiss has a full complement of players to choose from as Ian Madigan gets the nod at fly-half ahead of Paddy Jackson while Isaac Boss retains his position at scrum-half.
In the forwards, Dave Kilcoyne is replaced by Tom Court at loosehead prop with Rochardt Strauss at hooker and Mike Ross starting at tighthead.
Leinster flanker Kevin McLaughlin comes into the back row alongside Tommy O'Donnell while Devin Toner is joined by Dan Tuohy in the second row.
Meanwhile Canada coach Kieran Crowley has made four changes to the side which beat Tonga 36-27 in the Pacific Nations Cup last weekend.
Harry Jones is preferred at outside centre as Nick Blevins is reduced to the bench, while Taylor Paris takes to the left wing with Sean Duke left out of the match-day 23.
In the half-backs Sean White is replaced by Phil Mack at scrum-half while Nathan Hirayama retains his place at fly-half.
London Irish forward Jebb Sinclair switches from the back row to second row as Plymouth forward Brett Beukeboom is omitted and replaced by Tyler Ardron.
Canada: 15 James Pritchard, 14 Matt Evans, 13 Ciaran Hearn, 12 Harry Jones, 11 Taylor Paris, 10 Nathan Hirayama, 9 Phil Mack, 8 Aaron Carpenter (capt), 7 John Moonlight, 6 Tyler Ardron, 5 Tyler Hotson, 4 Jebb Sinclair, 3 Jason Marshall, 2 Ray Barkwill, 1 Hubert Buydens.
Replacements: 16 Ryan Hamilton, 17 Andrew Tiedemann, 18 Doug Wooldridge, 19 Jon Phelan, 20 Nanyak Dala, 21 Sean White, 22 Nick Blevins, 23 Connor Braid.
15 Felix Jones, 14 Fergus McFadden, 13 Darren Cave, 12 James Downey, 11 Andrew Trimble, 10 Ian Madigan, 9 Isaac Boss, 8 Peter O'Mahony (capt), 7 Tommy O'Donnell, 6 Kevin McLaughlin, 5 Devin Toner, 4 Dan Tuohy, 3 Mike Ross, 2 Richardt Strauss, 1 Tom Court.
Replacements: 16 Sean Cronin, 17 David Kilcoyne, 18 Declan Fitzpatrick, 19 Mike McCarthy, 20 Chris Henry, 21 Paul Marshall, 22 Paddy Jackson, 23 Robbie Henshaw.
"We look forward to hosting Ireland at BMO Field and to the formidable challenge they bring.
"Ireland are a world-class side and this game will be a good opportunity for us to measure ourselves against one of the best."
"We are anticipating a tough game against a very good Canada side that have put together a run of three wins in the Pacific Nations Cup.
"The experience gained on this tour is invaluable and I have no doubt that the players will respond well in what will be another challenging test."
|Saturday 30th November|
|Wales 26 - 30 Australia|
|Barbarians 43 - 19 Fiji|
|Sunday 24th November|
|Ireland 22 - 24 New Zealand|
|Saturday 23rd November|
|France 10 - 19 South Africa|
|Scotland 15 - 21 Australia|
|Italy 14 - 19 Argentina|
|Friday 22nd November|
|Wales 17 - 7 Tonga|
|Sunday 17th November|
|Scotland 0 - 28 South Africa|
|Saturday 16th November|
|Ireland 15 - 32 Australia|
|France 38 - 18 Tonga|
|Wales 40 - 6 Argentina|
|England 22 - 30 New Zealand|
|Italy 37 - 31 Fiji|
|Saturday 9th November|
|France 19 - 26 New Zealand|
|Ireland 40 - 9 Samoa|
|Wales 15 - 24 South Africa|
|Scotland 42 - 17 Japan|
|England 31 - 12 Argentina|
|Italy 20 - 50 Australia|
|Saturday 2nd November|
|England 20 - 13 Australia|
|Japan 6 - 54 New Zealand|
|Saturday 19th October|
|New Zealand 41 - 33 Australia|
Read the thoughts and opinions of Stuart Barnes with skysports.com