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South African World Cup-winning tighthead prop CJ van der Linde will make his London Irish debut in the Aviva Premiership clash at Sale Sharks on Friday night.
The Exiles also welcome back Ian Humphreys from injury and he will partner Tomas O'Leary at half-back.
Eamonn Sheridan and Fergus Mulchrone will form the centre partnership with Topsy Ojo, Andrew Fenby and James O'Connor in the back three.
Matt Parr, Jimmy Stevens and Van der Linde will start in the front row with Ian Gough and George Skivington in the second row. Blair Cowan, Jebb Sinclair and Chris Hala'ufia make up the back row.
Irish sit 11th out of 12 in the Premiership, and rugby director Brian Smith admitted clashes with fellow strugglers Gloucester and Worcester after Friday's contest have teed up a pivotal Christmas run.
He said: "We've got some artillery there that we've been holding back for the last two weeks, with good reason.
"These next three league games are massive for us, and I think we're a good enough rugby team to win all three.
"But we've definitely got to step up to the plate. On a Saturday afternoon when the sun's shining you can play the brand of rugby we love to play, and move the ball around.
"But if you go in with the intentions of doing that on a Friday night in Manchester, it simply won't suit the conditions."
For Sale, Danny Cipriani continues at fly-half after his impressive 28-point haul against Oyonnax in the Challenge Cup.
A new second-row pairing sees Jonathan Mills partner Michael Paterson in the engine room.
Prop Eifion Lewis-Roberts will make his 100th Premiership appearance if he joins Friday's fray from the bench.
Former London Welsh captain Mills has challenged eighth-placed Sale to start their Christmas league schedule with a win, especially with trips to Leicester and Newcastle in the festive offing.
"Friday is the start of three crucial Premiership games for us," Mills told the Manchester Evening News.
"And if we can win two out of those three games it will really set the season up for us."
Sale: Miller, Brady, Jennings, Tuitupou, Cueto, Cipriani, Peel; Harrison, Taylor, Cobilas, Mills, Paterson, Braid, Seymour, Gaskell
Replacements: Jones, Lewis-Roberts, Thomas, Kulemin, Ostrikov, Cliff, Ford, Mckenzie
London Irish: O'Connor, Ojo, Mulchrone, Sheridan, Fenby, Humphreys, O'Leary; Parr, Stevens, Van der Linde, Skivington, Gough, Sinclair, Cowan, Hala'ufia
Replacements: Mayhew, Yapp, Halavatau, Rouse, Treviranus, Lewington, Geraghty, Allinson
|Friday 21st March|
|19:45||Worcester vs Wasps|
|Saturday 22nd March|
|14:00||Sale vs Northampton|
|15:00||Gloucester vs Newcastle|
|15:15||Saracens vs Harlequins|
|17:30||London Irish vs Bath|
|Sunday 23rd March|
|14:00||Leicester vs Exeter|
|Friday 28th March|
|19:45||Bath vs Sale|
|Saturday 29th March|
|15:00||Wasps vs Saracens|
|15:00||Harlequins vs London Irish|
|15:00||Exeter vs Gloucester|
|15:15||Northampton vs Leicester|
|Sunday 30th March|
|14:00||Newcastle vs Worcester|
|Friday 11th April|
|19:45||Sale vs Harlequins|
|Saturday 12th April|
|15:00||Worcester vs Exeter|
|15:00||Leicester vs Wasps|
|15:15||Gloucester vs Bath|
|Sunday 13th April|
|14:00||Saracens vs Northampton|
|15:00||London Irish vs Newcastle|
|Friday 18th April|
|19:45||Harlequins vs Leicester|
|Saturday 19th April|
|15:00||Bath vs Worcester|
|15:00||Exeter vs Sale Sharks|
|15:15||Wasps vs Gloucester|
|Sunday 20th April|
|14:00||Northampton vs London Irish|
|15:00||Newcastle vs Saracens|
|Saturday 3rd May|
|15:00||Bath vs Northampton|
|Sunday 2nd March|
|Newcastle 18 - 41 Leicester|
|Saturday 1st March|
|Northampton 39 - 13 Gloucester|
|Exeter 18 - 0 London Irish|
|Harlequins 21 - 20 Worcester|
|Wasps 17 - 21 Sale Sharks|
|Friday 28th February|
|Bath 10 - 23 Saracens|
|Sunday 23rd February|
|Saracens 23 - 10 Exeter|
|Newcastle 16 - 22 Northampton|
|London Irish 15 - 20 Leicester|
|Saturday 22nd February|
|Worcester 12 - 24 Sale Sharks|
|Bath 32 - 25 Wasps|
|Gloucester 25 - 20 Harlequins|
|Sunday 16th February|
|Leicester 11 - 8 Gloucester|
|Saturday 15th February|
|Exeter 23 - 27 Bath|
|Wasps 20 - 23 London Irish|
|Northampton 30 - 14 Worcester|
|Harlequins 18 - 14 Newcastle|
|Friday 14th February|
|Sale Sharks 10 - 15 Saracens|
|Sunday 9th February|
|Harlequins 11 - 10 Wasps|
|Saturday 8th February|
|Exeter 16 - 17 Northampton|
|Saracens 13 - 22 London Irish|
|Bath 24 - 6 Newcastle|
|Friday 7th February|
|Sale Sharks 24 - 19 Gloucester|
|Worcester 22 - 23 Leicester|
Read the thoughts and opinions of Stuart Barnes with skysports.com