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Northampton Saints will be aiming to consolidate their place at the top of the Aviva Premiership table when they host rock-bottom Worcester at Franklin's Gardens on Saturday.
Dean Ryan's troops face a daunting task as the Saints have won their last nine contests in all-competitions and have not been defeated at home in the Premiership for nearly a year.
Meanwhile, relegation-threatened Warriors are still searching for their first win of the league season having lost their last 22 away games. Another loss would break Rotherham's all-time record of defeats from 2000 to 2004.
Saints have made four changes to their starting XV with Lee Dickson returning from England duty to partner Stephen Myler at half-back, with Kahn Fotuali'i dropping to the bench.
Elsewhere Dom Waldouck and Christian Day have picked up leg injuries which have ruled them out of the contest.
Waldouck is replaced by Tom Stephenson, who has scored two tries in his opening two outings for England U20 in the Six Nations.
Day's absence sees Sam Dickinson move up into the second row, with GJ Van Velze starting at number eight and Teimana Harrison taking Van Velze's place on the bench.
Dean Schofield and Leonardo Senatore return to the Warriors starting line-up.
Schofield comes in at lock while Senatore is named at flanker, as director of rugby Dean Ryan makes just two changes to the side which almost defeated Leicester Tigers last Friday.
"The short-term aim for us is to get this group at its best and see if we can compete because we're desperate to fight the challenge of relegation," said Ryan.
"We did a pretty good job against Northampton for 65 minutes when they came to Sixways earlier this season.
"Since then we've proved that as a group we are able to last longer and hopefully we can make things difficult.
"A lot of people did themselves a lot of credit against Leicester last week so they deserve to roll again.
"Saints have huge resources. They've got academy players that step up to Premiership level when players are away on international duty."
Northampton: 15 Wilson, 14 Pisi, 13 Pisi, 12 Stephenson, 11 Elliott, 10 Myler, 9 Dickson; 1 Waller, 2 Haywood, 3 Ma'afu, 4 Manoa, 5 Dickinson, 6 Clark, 7 Dowson (Capt), 8 van Velze.
Replacements: 16 McMillan, 17 Waller, 18 Denman, 19 Nutley, 20 Harrison, 21 Fotuali'i, 22 Hooley, 23 Auagavaia.
Worcester: 15 Pennell, 14 Drauniniu, 13 Grove, 12 Fatiaki, 11 Lemi, 10 Warwick. 9 Arr; 1 Fainga'anuku, 2 Creevy, 3 Andress, 4 Schofield, 5 Galarza, 6 Senatore, 7 Betty, 8 Thomas (Capt).
Replacements: 16 Brooker, 17 Porter, 18 O'Donnell, 19 Percival, 20 de Carpentier, 21 Hodgson, 22 Mieres, 23 Hammond.
|Click here for more betting|
|Friday 18th April|
|19:45||Harlequins vs Leicester|
|Saturday 19th April|
|15:00||Bath vs Worcester|
|15:00||Exeter vs Sale|
|15:15||Wasps vs Gloucester|
|Sunday 20th April|
|14:00||Northampton vs London Irish|
|15:00||Newcastle vs Saracens|
|Saturday 3rd May|
|15:00||Bath vs Northampton|
|15:00||Saracens vs Worcester|
|15:00||Exeter vs Harlequins|
|15:00||Gloucester vs London Irish|
|15:00||Sale vs Leicester|
|15:00||Wasps vs Newcastle|
|Saturday 10th May|
|15:15||Newcastle vs Exeter|
|15:15||Leicester vs Saracens|
|15:15||Northampton vs Wasps|
|15:15||Worcester vs Gloucester|
|15:15||Harlequins vs Bath|
|15:15||London Irish vs Sale|
|Sunday 13th April|
|London Irish 40 - 12 Newcastle|
|Saracens 28 - 24 Northampton|
|Saturday 12th April|
|Gloucester 17 - 18 Bath|
|Worcester 33 - 38 Exeter|
|Leicester 27 - 15 Wasps|
|Friday 11th April|
|Sale Sharks 12 - 27 Harlequins|
|Sunday 30th March|
|Newcastle 12 - 17 Worcester|
|Saturday 29th March|
|Northampton 16 - 22 Leicester|
|Wasps 20 - 32 Saracens|
|Exeter 13 - 14 Gloucester|
|Harlequins 23 - 9 London Irish|
|Friday 28th March|
|Bath 11 - 12 Sale Sharks|
|Sunday 23rd March|
|Leicester 45 - 15 Exeter|
|Saturday 22nd March|
|London Irish 23 - 44 Bath|
|Saracens 39 - 17 Harlequins|
|Gloucester 40 - 33 Newcastle|
|Sale Sharks 19 - 6 Northampton|
|Friday 21st March|
|Worcester 11 - 13 Wasps|
|Sunday 2nd March|
|Newcastle 18 - 41 Leicester|
|Saturday 1st March|
|Northampton 39 - 13 Gloucester|
|Exeter 18 - 0 London Irish|
|Harlequins 21 - 20 Worcester|
|Wasps 17 - 21 Sale Sharks|
|Friday 28th February|
|Bath 10 - 23 Saracens|
Read the thoughts and opinions of Phil Edwards with skysports.com