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Harlequins head into their clash against Newcastle Falcons on Saturday having suffered just one defeat in their last six home matches in all-competitions.
Their last four matches in the Aviva Premiership have all been won by the home side, so they will be favourites to pick up a win against their opponents at Twickenham Stoop.
The Falcons, meanwhile, have slipped to seven straight defeats in the competition and are 11th in the table but well clear of bottom side Worcester.
Harlequins have made three changes to the starting side which beat London Wasps last weekend.
Tom Casson is named at outside centre, partnering Jordan Turner-Hall while Ben Botica starts at fly-half in place of Nick Evans who picked up a foot injury last week.
In the forwards, the front five remain unchanged, while Luke Wallace starts at openside flanker and Maurie Fa'asavalu switches to the blindside. Number eight Nick Easter captains the side.
The Falcons are looking to bounce back from their 24-6 defeat to Bath at The Rec with Scott Lawson returning at hooker exactly a week after winning his 40th cap for Scotland against England in the Calcutta Cup.
The experienced front-rower, 32, is one of five changes to the side with fellow Scot Mike Blair starting for the first time since the turn of the year.
Blair, the most capped Scotland scrum-half of all time, partners former Quins man Rory Clegg at half-back, while Ryan Shortland gets the nod on the wing in place of Sinoti Sinoti who is sidelined with an ankle injury.
"They are a spritely sort of side and they like to move the ball around and hold onto it for long periods," said head coach Peter Russell.
"We have to try and nullify that by bringing the kind of defensive game we showed down at Bath."
Harlequins: 15 Lindsay-Hague, 14 Smith, 13 Casson, 12 Turner-Hall, 11 Monye, 10 Botica, 9 Dickson; 1 Lambert, 2 Ward, 3 Doran Jones, 4 Kennedy, 5 Matthews, 6 Fa'asavalu, 7 Wallace, 8 Easter.
Replacements: 16 Gray, 17 Marfo, 18 Sinckler, 19 Guest, 20 Trayfoot, 21 Stuart, 22 Grimoldby, 23 Sackey.
Newcastle: 15 Cato, 14 Tait, 13 Tiesi, 12 Helleur, 11 Shortland, 10 Clegg, 9 Blair; 1 Vickers, 2 Lawson, 3 Brookes, 4 MacLeod, 5 McKenzie, 6 Welch (c), 7 Saull, 8 Wilson.
Replacements: 16 McGuigan, 17 Strain, 18 Tomaszczyk, 19 Tomes, 20 Hogg, 21 Fury, 22 Hodgson, 23 Powell.
|Click here for more betting|
|Friday 18th April|
|19:45||Harlequins vs Leicester|
|Saturday 19th April|
|15:00||Bath vs Worcester|
|15:00||Exeter vs Sale|
|15:15||Wasps vs Gloucester|
|Sunday 20th April|
|14:00||Northampton vs London Irish|
|15:00||Newcastle vs Saracens|
|Saturday 3rd May|
|15:00||Bath vs Northampton|
|15:00||Saracens vs Worcester|
|15:00||Exeter vs Harlequins|
|15:00||Gloucester vs London Irish|
|15:00||Sale vs Leicester|
|15:00||Wasps vs Newcastle|
|Saturday 10th May|
|15:15||Newcastle vs Exeter|
|15:15||Leicester vs Saracens|
|15:15||Northampton vs Wasps|
|15:15||Worcester vs Gloucester|
|15:15||Harlequins vs Bath|
|15:15||London Irish vs Sale|
|Sunday 13th April|
|London Irish 40 - 12 Newcastle|
|Saracens 28 - 24 Northampton|
|Saturday 12th April|
|Gloucester 17 - 18 Bath|
|Worcester 33 - 38 Exeter|
|Leicester 27 - 15 Wasps|
|Friday 11th April|
|Sale Sharks 12 - 27 Harlequins|
|Sunday 30th March|
|Newcastle 12 - 17 Worcester|
|Saturday 29th March|
|Northampton 16 - 22 Leicester|
|Wasps 20 - 32 Saracens|
|Exeter 13 - 14 Gloucester|
|Harlequins 23 - 9 London Irish|
|Friday 28th March|
|Bath 11 - 12 Sale Sharks|
|Sunday 23rd March|
|Leicester 45 - 15 Exeter|
|Saturday 22nd March|
|London Irish 23 - 44 Bath|
|Saracens 39 - 17 Harlequins|
|Gloucester 40 - 33 Newcastle|
|Sale Sharks 19 - 6 Northampton|
|Friday 21st March|
|Worcester 11 - 13 Wasps|
|Sunday 2nd March|
|Newcastle 18 - 41 Leicester|
|Saturday 1st March|
|Northampton 39 - 13 Gloucester|
|Exeter 18 - 0 London Irish|
|Harlequins 21 - 20 Worcester|
|Wasps 17 - 21 Sale Sharks|
|Friday 28th February|
|Bath 10 - 23 Saracens|
Read the thoughts and opinions of Phil Edwards with skysports.com