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Toulouse have the chance to secure a home Heineken Cup quarter-final with a bonus-point win at Zebre on Saturday.
Victory at Stadio XXV Aprile would be enough to ensure top spot in Pool 3 but, depending a results elsewhere, the French side may need to score four tries to be sure of hosting a last-eight fixture.
Toulouse welcome the return of Vincent Clerc - the Heineken Cup's all-time leading try scorer - in a starting XV that features four changes to the side that beat Saracens last week.
With Clerc back, Yoann Huget switches wings to start on the left and Hosea Gear drops out of the squad.
Gael Fickou is promoted to the starting line-up at inside centre with Clement Poitrenaud moving to the bench, while Sebastian Bezy is preferred at scrum-half to Jano Vermaak.
In the pack, Joe Tekori is named in the second row as Patricio Albacete is given a rest. Prop Cyril Baille and Fijian flyer Timoci Matanavou are added to the replacements.
Zebre have lost all five of their matches in the competition, conceding 94 points along the way.
There are five changes from the team that lost away to Connacht last week, including the return of former All Black Brendon Leonard and Mauro Bergamasco.
Zebre: 15 Trevisan, 14 Sarto, 13 Ratuvou, 12 Garcia, 11 Berryman, 10 Orquera, 9 Leonard; 1 Ageuro, 2 D'Apice, 3 Chistolini, 4 Geldenhuys (capt), 5 Biagi, 6 Bergamasco, 7 Van Schalkwyk, 8 Vunisa
Replacements:16 Leibson, 17 De Marchi, 18 Redolfini, 19 Caffini, 20 Cristiano, 21 Chillon, 22 Quartaroli, 23 Gullo
Toulouse: 15 Medard, 14 Clerc, 13 David, 12 Fickou, 11 Huget, 10 Doussain, 9 Bezy; 1 Ferreira, 2 Ralepelle, 3 Johnston, 4 Maestri, 5 Tekori, Nyanga, Dusautoir (capt), 8 Picamoles
Replacements: 16 Tolofua, 17 Baille, 18 Montes, 19 Millo-Chluski, 20 Camara, 21 Vermaak, 22 Poitrenaud, 23 Matanavou
Read the thoughts and opinions of Stuart Barnes with skysports.com