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Winger Mark Cueto is welcomed back to the Sale Sharks line-up by Director of Rugby Steve Diamond as they take on Oyonnax in Friday's Amlin Challenge Cup Pool 1 clash at the AJ Bell Stadium.
Sammy Tuitupou, Danny Cipriani and Dwayne Peel also return to the starting line-up as the Sharks look to consolidate their position at the top of the pool.
In the away game at Oyonnax last week the hosts won 16-10, in what was their first ever win in the Challenge Cup, having previously drawn at home to Worcester and lost at Biarritz.
Meanwhile, Oyonnax field a much-changed side from that first leg victory on Friday, with Jonathan Bousquet switching from wing to full-back, Dug Codjo coming in out wide, Romaita Hansell Pune starting at inside centre.
There is a new half-back pairing in the form of scrum-half Fabien Cibray and pivot Nicolas Vuillemin, but the front-row remains unchanged.
Elsewhere in the pack, Miroslav Nemecek is replaced at second-row by Thibault Lassale, and Christophe Andre comes in at openside flanker with Chad Slade moving to number eight.
Sale Sharks: 15 Miller, 14 Brady, 13 Jennings, 12 Tuitupou, 11 Cueto, 10 Cipriani, 9 Peel, 8 Gaskell, 7 Seymour, 6 Braid, 5 Kulemin, 4 Cobilas, 3 Ostrikov, 2 Taylor, 1 Harrison
Replacements: 16 Jones, 17 Flynn, 18 Buckley, 19 Mills, 20 Paterson, 21 Cliff, 22 Ford, 23 Forsyth
Oyonnax: 15 Bousquet, 14 Codjo, 13 Bousses, 12 Hansell Pune, 11 Koroivoutu, 10 Vuillemin, 9 Cibray, 8 Slade (c), 7 Andre, 6 Diaby, 5 Lagrange, 4 Lassale, 3 Du Preez, 2 Clark, 1 Iapteff
Replacements: 16 Rapant, 17 Tichit, 18 Baiocco, 19 El Abd, 20 Authier, 21 Paea, 22 Aguillon, 23 Nemecek
Read the thoughts and opinions of Stuart Barnes with skysports.com