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Premiership champions Harlequins have made two changes to the starting line-up that defeated Leicester Tigers last weekend.
In the backs, Karl Dickson returns to start at scrum-half for Danny Care who is on England duty alongside Mike Brown, Joe Marler and Chris Robshaw.
Ben Botica continues at fly-half while Nick Evans recovers from an ankle injury which ruled him out of last week's fixture. Evans will be fit to return next week against the Exeter Chiefs.
In the forwards, Tom Guest has not fully recovered from a knock picked up during the win against Leicester, so Captain Nick Easter returns to the back-row alongside Maurie Fa'asavalu and Luke Wallace.
With Botica starting, Rory Clegg returns from Leeds and is is named among the replacements.
Meanwhile, Sale Sharks are hoping to maintain their winning run that started four games ago with a win over Scarlets in the LV-Cup.
Since then, the Sharks have been to Wasps and inflicted their first defeat at Adams Park this season and added the scalps of Exeter Chiefs and London Welsh.
Harlequins however are probably the toughest test yet, having won their last five away games. Their last defeat away from the Stoop was last November when they lost 18-21 to Bath at The Rec.
Sale Sharks: 15 Rob Miller, 14 Charlie Amesbury, 13 Jonny Leota, 12 Sammy Tuitupou, 11 Mark Cueto, 10 Danny Cipriani, 9 Will Cliff, 8 James Gaskell 7 David Seymour (c), 6 Dan Braid, 5 Kearnan Myall, 4 Fraser McKenzie, 3 Henry Thomas, 2 Tommy Taylor, 1 Ross Harrison.
Replacements: 16 Marc Jones, 17 Eifion Lewis-Roberts, 18 Tony Buckley, 19 Tom Holmes, 20 Richie Vernon, 21 Cillian Willis, 22 Nick Macleod, 23 Will Addison
Harlequins: 15 Ross Chisholm, 14 Tom Williams, 13 Matt Hopper, 12 Jordan Turner-Hall, 11 Ugo Monye, 10 Ben Botica, 9 Karl Dickson, 8 Nick Easter (c), 7 Luke Wallace, 6 Maurie Fa'asavalu, 5 George Robson, 4 Charlie Matthews, 3 James Johnston, 2 Joe Gray, 1 Mark Lambert.
Replacements: 16 Rob Buchanan, 17 Darryl Marfo, 18 Will Collier, 19 Sam Twomey, 20 Joe Trayfoot, 21 Jordan Burns, 22 Rory Clegg, 23 George Lowe.
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|Saturday 22nd March|
|15:15||Saracens vs Harlequins|
|Saturday 29th March|
|15:00||Harlequins vs London Irish|
|Friday 4th April|
|Amlin Challenge Cup|
|20:00||Stade Francais vs Harlequins|
|Friday 11th April|
|19:45||Sale vs Harlequins|
|Friday 18th April|
|19:45||Harlequins vs Leicester|
|Saturday 3rd May|
|15:00||Exeter vs Harlequins|
|Saturday 10th May|
|15:15||Harlequins vs Bath|
|Saturday 1st March|
|Harlequins 21 - 20 Worcester|
|Saturday 22nd February|
|Gloucester 25 - 20 Harlequins|
|Saturday 15th February|
|Harlequins 18 - 14 Newcastle|
|Sunday 9th February|
|Harlequins 11 - 10 Wasps|
|Friday 31st January|
|Cardiff Blues 35 - 5 Harlequins|
|Saturday 25th January|
|Harlequins 20 - 6 Leicester|
|Sunday 19th January|
|Scarlets 20 - 22 Harlequins|
Read the thoughts and opinions of Stuart Barnes with skysports.com