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Premiership champions Harlequins have made two changes to the starting line-up that defeated Leicester Tigers last weekend.
In the backs, Karl Dickson returns to start at scrum-half for Danny Care who is on England duty alongside Mike Brown, Joe Marler and Chris Robshaw.
Ben Botica continues at fly-half while Nick Evans recovers from an ankle injury which ruled him out of last week's fixture. Evans will be fit to return next week against the Exeter Chiefs.
In the forwards, Tom Guest has not fully recovered from a knock picked up during the win against Leicester, so Captain Nick Easter returns to the back-row alongside Maurie Fa'asavalu and Luke Wallace.
With Botica starting, Rory Clegg returns from Leeds and is is named among the replacements.
Meanwhile, Sale Sharks are hoping to maintain their winning run that started four games ago with a win over Scarlets in the LV-Cup.
Since then, the Sharks have been to Wasps and inflicted their first defeat at Adams Park this season and added the scalps of Exeter Chiefs and London Welsh.
Harlequins however are probably the toughest test yet, having won their last five away games. Their last defeat away from the Stoop was last November when they lost 18-21 to Bath at The Rec.
Sale Sharks: 15 Rob Miller, 14 Charlie Amesbury, 13 Jonny Leota, 12 Sammy Tuitupou, 11 Mark Cueto, 10 Danny Cipriani, 9 Will Cliff, 8 James Gaskell 7 David Seymour (c), 6 Dan Braid, 5 Kearnan Myall, 4 Fraser McKenzie, 3 Henry Thomas, 2 Tommy Taylor, 1 Ross Harrison.
Replacements: 16 Marc Jones, 17 Eifion Lewis-Roberts, 18 Tony Buckley, 19 Tom Holmes, 20 Richie Vernon, 21 Cillian Willis, 22 Nick Macleod, 23 Will Addison
Harlequins: 15 Ross Chisholm, 14 Tom Williams, 13 Matt Hopper, 12 Jordan Turner-Hall, 11 Ugo Monye, 10 Ben Botica, 9 Karl Dickson, 8 Nick Easter (c), 7 Luke Wallace, 6 Maurie Fa'asavalu, 5 George Robson, 4 Charlie Matthews, 3 James Johnston, 2 Joe Gray, 1 Mark Lambert.
Replacements: 16 Rob Buchanan, 17 Darryl Marfo, 18 Will Collier, 19 Sam Twomey, 20 Joe Trayfoot, 21 Jordan Burns, 22 Rory Clegg, 23 George Lowe.
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|Sunday 15th December|
|12:45||Harlequins vs Racing Metro 92|
|Saturday 21st December|
|15:00||Bath vs Harlequins|
|Saturday 28th December|
|15:00||Harlequins vs Exeter|
|Saturday 11th January|
|TBC||Harlequins vs Clermont Auvergne|
|Saturday 18th January|
|TBC||Scarlets vs Harlequins|
|Saturday 25th January|
|15:00||Harlequins vs Leicester|
|Friday 31st January|
|19:05||Cardiff Blues vs Harlequins|
|Saturday 8th February|
|15:00||Harlequins vs Wasps|
|Saturday 15th February|
|15:00||Harlequins vs Newcastle|
|Saturday 22nd February|
|15:00||Gloucester vs Harlequins|
|Saturday 1st March|
|15:00||Harlequins vs Worcester|
|Saturday 22nd March|
|15:00||Saracens vs Harlequins|
|Saturday 7th December|
|Racing Metro 92 8 - 32 Harlequins|
|Sunday 1st December|
|Newcastle 9 - 35 Harlequins|
|Saturday 23rd November|
|Harlequins 27 - 19 Gloucester|
|Friday 15th November|
|Harlequins 26 - 31 Sale Sharks|
|Saturday 9th November|
|Exeter 19 - 5 Harlequins|
|Saturday 2nd November|
|Leicester 16 - 23 Harlequins|
|Saturday 26th October|
|Harlequins 24 - 3 Sale Sharks|
Read the thoughts and opinions of Stuart Barnes with skysports.com