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Saracens and England centre Joel Tomkins is facing three months out of action after picking up a knee injury while on international duty.
Sarries director of rugby Mark McCall revealed the news after his side had ground out a hard-fought 16-9 victory over Exeter Chiefs at Sandy Park to maintain their place at the top of the Aviva Premiership.
Tomkins missed the trip to Devon, and McCall said: "Joel has got a knee injury, and will be out for quite some time, probably three months.
"He picked up the injury in the last five minutes of the game against New Zealand and it is a maximum 12-week injury."
Saracens were also without England fly-half Owen Farrell, while his replacement Charlie Hodgson went off with a bang to the head after only two minutes on Saturday, but McCall said they would both be fit for next weekend's home game against Sale.
"Owen is resting after three busy weeks with England, and he has played a lot for us, with Charlie not being around for the first six weeks, but he will be back for next week," McCall said.
"Charlie is fine. He got a knock on the head, and you have to be careful these days. You don't want to take any risks."
Exeter assistant coach Ali Hepher felt Exeter deserved more than just a losing bonus point out of the contest after the TMO ruled out two scores.
"We put a lot into the game and if you look at the overall game, I think a draw would have been a fair result, but it wasn't to be," he said.
"We came up a little bit short with the two TMO decisions we had, and if one of those had been given, that might have changed the game.
"We have got to take them on the chin, those decisions probably even themselves out throughout the season, but we are certainly disappointed.
"It was frustrating the referee went to the TMO for Tom's one, because we had possession of the ball, and we only needed one more phase round the corner, and we would have walked the ball in.
"We were robbed of that opportunity when the referee went to the TMO.
"Overall, we attacked the game and went after Saracens. They are probably the best defensive side in the league and we created opportunities against them, but we made a couple of errors that probably cost us."Aviva Premiership. Click here to bet.
|Friday 2nd May|
|19:45||Bath vs Northampton|
|Saturday 3rd May|
|15:00||Saracens vs Worcester|
|15:00||Wasps vs Newcastle|
|15:00||Gloucester vs London Irish|
|15:15||Sale vs Leicester|
|Sunday 4th May|
|14:00||Exeter vs Harlequins|
|Saturday 10th May|
|15:15||Newcastle vs Exeter|
|15:15||Northampton vs Wasps|
|15:15||Worcester vs Gloucester|
|15:15||Leicester vs Saracens|
|15:15||Harlequins vs Bath|
|15:15||London Irish vs Sale|
|Sunday 20th April|
|Newcastle 18 - 23 Saracens|
|Northampton 36 - 21 London Irish|
|Saturday 19th April|
|Wasps 38 - 30 Gloucester|
|Bath 32 - 20 Worcester|
|Exeter 12 - 55 Sale|
|Friday 18th April|
|Harlequins 24 - 20 Leicester|
|Sunday 13th April|
|London Irish 40 - 12 Newcastle|
|Saracens 28 - 24 Northampton|
|Saturday 12th April|
|Gloucester 17 - 18 Bath|
|Worcester 33 - 38 Exeter|
|Leicester 27 - 15 Wasps|
|Friday 11th April|
|Sale Sharks 12 - 27 Harlequins|
|Sunday 30th March|
|Newcastle 12 - 17 Worcester|
|Saturday 29th March|
|Northampton 16 - 22 Leicester|
|Wasps 20 - 32 Saracens|
|Exeter 13 - 14 Gloucester|
|Harlequins 23 - 9 London Irish|
|Friday 28th March|
|Bath 11 - 12 Sale Sharks|
|Sunday 23rd March|
|Leicester 45 - 15 Exeter|
|Saturday 22nd March|
|London Irish 23 - 44 Bath|
|Saracens 39 - 17 Harlequins|
|Gloucester 40 - 33 Newcastle|
|Sale Sharks 19 - 6 Northampton|
|Friday 21st March|
|Worcester 11 - 13 Wasps|
Read the thoughts and opinions of Stuart Barnes with skysports.com