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Exeter completed an Aviva Premiership double over Harlequins with a 27-16 victory over the leaders and champions at the Twickenham Stoop.
The Chiefs needed a win to maintain their push for a Heineken Cup place and after a tense 60 minutes, they seized control with two tries in seven minutes.
Harlequins looked anything but a side with legitimate ambitions for an unprecedented treble as they disintegrated under pressure in the final quarter.
Quins appeared set to avenge October's defeat at Sandy Park as they raced ahead after just six minutes with a sublime try from Ugo Monye.
Quick lineout ball was swept out wide and with decoy runners seemingly everywhere, Monye arrived on a superb line to take a flat ball from Jordan Turner-Hall and charge over, with Nick Evans adding the extras.
But Exeter's gameplan was based around discipline and patience and they chipped away at the lead over the next 10 minutes, Gareth Steenson knocking over two penalties.
Evans missed a kick at goal from the touchline, before a charge up the middle by Jack Nowell earned the Chiefs a penalty for offside, which Steenson kicked.
Quins regained the lead when Alex Brown conceded a penalty as a scrum collapsed and this time Evans found the target, but when Ben Botica took over the kicking duties on the stroke of half-time, he missed a very kickable chance.
Two minutes into the second half Quins were penalised for hands in at a ruck and Steenson duly put the visitors ahead again at 12-10.
The game was turning into a kicking contest and two penalties from Botica followed, before Steenson kicked his fifth from five.
But just past the hour Exeter blew the game wide open. Steenson skipped and weaved his way through midfield and raced clear, only for Luke Arscott to knock on Matt Jess' pass 10 metres out with the line at his mercy.
It was only a temporary reprieve for Quins as three minutes later Steenson again broke through close to the line, before the ball was recycled and shippped out wide for Damian Welch to crash over.
Steenson's missed conversion was the only blip in a superb individual display from the fly-half and it made no difference as from a Quins drop-out, Arscott burst straight through the centre of a tired defence before diving gleefully over by the sticks to seal a deserved victory for Exeter.
|Friday 18th April|
|19:45||Harlequins vs Leicester|
|Saturday 19th April|
|15:00||Bath vs Worcester|
|15:00||Exeter vs Sale|
|15:15||Wasps vs Gloucester|
|Sunday 20th April|
|14:00||Northampton vs London Irish|
|15:00||Newcastle vs Saracens|
|Saturday 3rd May|
|15:00||Bath vs Northampton|
|15:00||Saracens vs Worcester|
|15:00||Exeter vs Harlequins|
|15:00||Gloucester vs London Irish|
|15:00||Sale vs Leicester|
|15:00||Wasps vs Newcastle|
|Saturday 10th May|
|15:15||Newcastle vs Exeter|
|15:15||Leicester vs Saracens|
|15:15||Northampton vs Wasps|
|15:15||Worcester vs Gloucester|
|15:15||Harlequins vs Bath|
|15:15||London Irish vs Sale|
|Sunday 13th April|
|London Irish 40 - 12 Newcastle|
|Saracens 28 - 24 Northampton|
|Saturday 12th April|
|Gloucester 17 - 18 Bath|
|Worcester 33 - 38 Exeter|
|Leicester 27 - 15 Wasps|
|Friday 11th April|
|Sale Sharks 12 - 27 Harlequins|
|Sunday 30th March|
|Newcastle 12 - 17 Worcester|
|Saturday 29th March|
|Northampton 16 - 22 Leicester|
|Wasps 20 - 32 Saracens|
|Exeter 13 - 14 Gloucester|
|Harlequins 23 - 9 London Irish|
|Friday 28th March|
|Bath 11 - 12 Sale Sharks|
|Sunday 23rd March|
|Leicester 45 - 15 Exeter|
|Saturday 22nd March|
|London Irish 23 - 44 Bath|
|Saracens 39 - 17 Harlequins|
|Gloucester 40 - 33 Newcastle|
|Sale Sharks 19 - 6 Northampton|
|Friday 21st March|
|Worcester 11 - 13 Wasps|
|Sunday 2nd March|
|Newcastle 18 - 41 Leicester|
|Saturday 1st March|
|Northampton 39 - 13 Gloucester|
|Exeter 18 - 0 London Irish|
|Harlequins 21 - 20 Worcester|
|Wasps 17 - 21 Sale Sharks|
|Friday 28th February|
|Bath 10 - 23 Saracens|
Read the thoughts and opinions of Stuart Barnes with skysports.com