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Agen came from behind to claim a 19-9 Amlin Challenge Cup win of the season at the expense of Calvisano in Pool Four.
Italy international scrum-half Paul Griffen kicked Calvisano into a 6-0 lead before Julien Janaudy ran in the first try of the night, Raphael Lagarde converting to nudge Agen ahead.
A third Griffen penalty followed but the Italians would not score again after the break, Lagarde adding two more points from Pierre Julien and Antoine Erbani's decisive tries.
Agen's third win of the campaign guarantees them a second-place finish in Pool Four, well behind leaders Bath.
Read the thoughts and opinions of Stuart Barnes with skysports.com