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Ireland brushed Scotland aside in their Six Nations opener, winning 28-6 in Dublin with tries from Andrew Trimble, Jamie Heaslip and Rob Kearney.
Jonathan Sexton kicked three penalties and two conversions, while Scotland's only points came from two Greig Laidlaw penalties.
Leinster number eight Heaslip assumed the captaincy after Paul O'Connell was ruled out by a chest infection on Saturday night and the stand-in skipper shrugged off a disallowed try to claim the score that broke Scotland's resistance.
Scotland dominated territory and possession in a gritty first-half, only for Ireland to break that stranglehold in the final exchanges.
The visitors were prepared to whip the ball wide at every turn, but in doing so failed to find sufficient midfield incision.
Impressive number eight David Denton powered close after a scrum deep in the Ireland 22, that followed the hosts failing to clear their lines on a number of occasions.
After that Scotland were unable to threaten seriously again in the half, with Duncan Weir's drop-goal fake not leading to any gain.
Laidlaw struck the post with a penalty after five minutes, and later he punted to the corner when he should have shot at goal.
Scotland lost the ensuing line-out, squandering any points at all in going for the ill-judged jugular of a try.
Crucially the hosts kept defensive shape and discipline, admittedly escaping punishment when O'Driscoll was rushed into a blind pass from a set scrum move that gifted Scotland good field position.
As time ticked down on the half, Sexton slinked through two Scotland tackles to race from danger zone to the other.
The Racing Metro fly-half fired out a pass to captain Heaslip, who cantered down the left wing heading for the corner.
The Leinster loose-forward touched down as he rolled the tackle, only for TMO Carlo Damasco to rule him in touch.
Ireland sustained the pressure from two driven line-outs in the Scotland 22 though, claiming just reward for persistence when Trimble went in at the right corner.
Heaslip capped a water-tight driven line-out as Ireland wrestled control after the break, bundling over to blunt the Scots' power.
Dave Kearney was forced into touch in his own 22 after misreading Weir's punt into the corner.
Toner hit a ruck from the side after the line-out to gift Scotland a penalty, and Laidlaw delivered the points from the tee.
Ireland then built tight phases for the first time in the match, Henry blasting in three times, with O'Mahony, Heaslip and Best all burrowing in too.
Sexton's wayward pass handed Scotland a scrum, but Ireland managed to turn it over.
Luke Marshall found Dave Kearney with a dangerous wide pass, before Ireland won a penalty with Scotland killing the ball.
Ireland punted to the corner, pushing for their second try and Heaslip delivered after a fine driven line-out.
Sexton, O'Driscoll and Dave Kearney produced a smart midfield combination that almost unlocked Scotland's dogged defence.
Sean Lamont strayed offside to hand Ireland a kickable penalty, and Sexton slotted his third goal of the day.
Weir's astute chip into the left corner forced Ireland into a pressure line-out five metres from their own line as Scotland battled for a foothold.
Replacement Jack McGrath produced a fine turnover to set Ireland back on the front foot, only for Tim Swinson to steal an intercept.
Ireland recovered the ascendancy though, with Sexton's tactical kicking to the fore.
And the hosts added their third try when Rob Kearney capped a neat break from Henry, for a score on his 50th cap.
Sexton converted to stretch Ireland's advantage to 22 points, before making way for Ulster's Paddy Jackson.
|RBS Six Nations|
|Sunday 9th March|
|RBS Six Nations|
|England 29 - 18 Wales|
|Saturday 8th March|
|Scotland 17 - 19 France|
|Ireland 46 - 7 Italy|
|Saturday 22nd February|
|England 13 - 10 Ireland|
|Italy 20 - 21 Scotland|
|Friday 21st February|
|Wales 27 - 6 France|
|Sunday 9th February|
|France 30 - 10 Italy|
|Saturday 8th February|
|Scotland 0 - 20 England|
|Ireland 26 - 3 Wales|
|Sunday 2nd February|
|Ireland 28 - 6 Scotland|
|Saturday 1st February|
|France 26 - 24 England|
|Wales 23 - 15 Italy|
Read the thoughts and opinions of Stuart Barnes with skysports.com