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Daniel Larrechea proved a more-than-able deputy for the injured Charlie Hodgson as he inspired Sale Sharks to a 17-12 victory against Harlequins.
The French fly-half scored 12 points in all, with the home side racing into a 14-3 lead at the break.
Harlequins struck back in the second half, however, with the boot of Adrian Jarvis bringing the London side two within two points of parity.
But opposite number Larrechea struck the telling blow, his third penalty of the match sealing victory for the reigning champions and bringing a positive end to a miserable few days.
Sale lost successive Guinness Premiership matches against Bristol and Newcastle - the latter defeat at home prompting an apology from director of rugby Phillipe Saint-Andre.
Then England number 10 Hodgson and prop Andrew Sheridan were ruled out for the rest of the season after suffering injuries during last Saturday's Test win against South Africa.
And to make matters worse, Scotland captain Jason White followed his club team mates into a lengthy rehabilitation.
Indeed, Sale's start to the match indicated more of the same for the Edgeley Park faithful, with an early Larrachea penalty miss followed by a successful kick from Jarvis.
But Larrachea gradually began to exert his influence on proceedings, some deft handling of the ball being backed up with a drop goal from the 'Quins 22 after 15 minutes that levelled the match.
A successful penalty then saw Larrachea edge Sale ahead, with the hosts scoring their first try in four matches after 22 minutes.
Poor handling in midfield was exploited by flanker Magnus Lund, the sometime England international combining well with centre Lee Thomas to exploit a gap in the Harlequins defence.
Although Larrachea failed to convert, another successful penalty conversion contributed to Sale's comfortable half-time lead.
Looking for their fourth win in a row, Harlequins mounted an impressive second half response, with Jarvis's first penalty pulling Harlequins back to within five points after 55 minutes.
And local hearts were certainly in mouths when a 45-metre Jarvis effort found its target with nine minutes remaining to secure the bonus point.
But it was left to Larrachea to ease the fears of Sharks fans, his fourth goal of the evening settling matters in favour of the home side and getting their title defence back on track.
|Friday 21st March|
|19:45||Worcester vs Wasps|
|Saturday 22nd March|
|14:00||Sale vs Northampton|
|15:00||Gloucester vs Newcastle|
|15:15||Saracens vs Harlequins|
|17:30||London Irish vs Bath|
|Sunday 23rd March|
|14:00||Leicester vs Exeter|
|Friday 28th March|
|19:45||Bath vs Sale|
|Saturday 29th March|
|15:00||Wasps vs Saracens|
|15:00||Harlequins vs London Irish|
|15:00||Exeter vs Gloucester|
|15:15||Northampton vs Leicester|
|Sunday 30th March|
|14:00||Newcastle vs Worcester|
|Friday 11th April|
|19:45||Sale vs Harlequins|
|Saturday 12th April|
|15:00||Worcester vs Exeter|
|15:00||Leicester vs Wasps|
|15:15||Gloucester vs Bath|
|Sunday 13th April|
|14:00||Saracens vs Northampton|
|15:00||London Irish vs Newcastle|
|Friday 18th April|
|19:45||Harlequins vs Leicester|
|Saturday 19th April|
|15:00||Bath vs Worcester|
|15:00||Exeter vs Sale Sharks|
|15:15||Wasps vs Gloucester|
|Sunday 20th April|
|14:00||Northampton vs London Irish|
|15:00||Newcastle vs Saracens|
|Saturday 3rd May|
|15:00||Bath vs Northampton|
|Sunday 2nd March|
|Newcastle 18 - 41 Leicester|
|Saturday 1st March|
|Northampton 39 - 13 Gloucester|
|Exeter 18 - 0 London Irish|
|Harlequins 21 - 20 Worcester|
|Wasps 17 - 21 Sale Sharks|
|Friday 28th February|
|Bath 10 - 23 Saracens|
|Sunday 23rd February|
|Saracens 23 - 10 Exeter|
|Newcastle 16 - 22 Northampton|
|London Irish 15 - 20 Leicester|
|Saturday 22nd February|
|Worcester 12 - 24 Sale Sharks|
|Bath 32 - 25 Wasps|
|Gloucester 25 - 20 Harlequins|
|Sunday 16th February|
|Leicester 11 - 8 Gloucester|
|Saturday 15th February|
|Exeter 23 - 27 Bath|
|Wasps 20 - 23 London Irish|
|Northampton 30 - 14 Worcester|
|Harlequins 18 - 14 Newcastle|
|Friday 14th February|
|Sale Sharks 10 - 15 Saracens|
|Sunday 9th February|
|Harlequins 11 - 10 Wasps|
|Saturday 8th February|
|Exeter 16 - 17 Northampton|
|Saracens 13 - 22 London Irish|
|Bath 24 - 6 Newcastle|
|Friday 7th February|
|Sale Sharks 24 - 19 Gloucester|
|Worcester 22 - 23 Leicester|
Read the thoughts and opinions of Stuart Barnes with skysports.com