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London Irish eased their relegation worries with a 22-13 victory at Saracens, the Premiership leaders' first defeat at Allianz Park this season.
The Exiles had won just one of their last six matches against Sarries but led 22-8 at the break thanks to tries from Matt Parr, Alex Lewington and George Skivington.
Saracens had led briefly through Marcelo Bosch's try in the 13th minute but - despite London Irish twice being reduced temporarily to 14 men - the league leaders failed to build any momentum.
Schalk Brits' try five minutes before the end gave them hope but Charlie Hodgson failed with the conversion attempt as Irish ran out 22-13 winners to give Northampton Saints the chance to take over at the top later in the day.
Shane Geraghty put the kick-off straight into touch but Saracens were penalised at the resulting scrum and, from the halfway line, James O'Connor put Irish ahead after three minutes.
After nine minutes Fergus Mulchrone was sent to the sin-bin for the Exiles after they were penalised at the breakdown for a fifth time in the opening minutes.
And five minutes later Saracens made their pressure pay. A quickly taken penalty five metres out was held up on the line but Hodgson spread the ball to Bosch on the overlap who went over for his first try for Saracens.
With Mulchrone back on the field the visitors grew into the game and they went ahead on 21 minutes through Parr's first Premiership try, the prop collecting Nic Rouse's off-load after clever play by Tomas O'Leary.
Blair Cowan became the second Exile to be sent to the bin but a Hodgson penalty was the hosts' only reward with the flanker off the pitch.
But the visitors shocked the home side with two tries in three first-half minutes as the match approached half-time.
First Hodgson's kick was charged down and O'Leary passed to winger Lewington, who crossed in the corner before Exiles captain Skivington went over on his return after scrappy play in midfield saw the ball kicked on several times.
O'Connor converted the latter having also added the extras to Parr's score to send the Exiles in 22-8 up at the break.
England centre Joel Tomkins made his return after three months out with a knee injury on 52 minutes.
With seven minutes remaining Brits broke through a gap in midfield to take play within 10 metres of the London Irish line.
The ball was recycled and spread wide before the visitors were penalised for a high tackle.
Saracens went for the scrum and finally burrowed over through Brits, though Hodgson's missed conversion ensured Sarries lost a regular season match for the first time at Allianz Park.
|Friday 21st March|
|19:45||Worcester vs Wasps|
|Saturday 22nd March|
|14:00||Sale vs Northampton|
|15:00||Gloucester vs Newcastle|
|15:15||Saracens vs Harlequins|
|17:30||London Irish vs Bath|
|Sunday 23rd March|
|14:00||Leicester vs Exeter|
|Friday 28th March|
|19:45||Bath vs Sale|
|Saturday 29th March|
|15:00||Wasps vs Saracens|
|15:00||Harlequins vs London Irish|
|15:00||Exeter vs Gloucester|
|15:15||Northampton vs Leicester|
|Sunday 30th March|
|14:00||Newcastle vs Worcester|
|Friday 11th April|
|19:45||Sale vs Harlequins|
|Saturday 12th April|
|15:00||Worcester vs Exeter|
|15:00||Leicester vs Wasps|
|15:15||Gloucester vs Bath|
|Sunday 13th April|
|14:00||Saracens vs Northampton|
|15:00||London Irish vs Newcastle|
|Friday 18th April|
|19:45||Harlequins vs Leicester|
|Saturday 19th April|
|15:00||Bath vs Worcester|
|15:00||Exeter vs Sale Sharks|
|15:15||Wasps vs Gloucester|
|Sunday 20th April|
|14:00||Northampton vs London Irish|
|15:00||Newcastle vs Saracens|
|Saturday 3rd May|
|15:00||Bath vs Northampton|
|Sunday 2nd March|
|Newcastle 18 - 41 Leicester|
|Saturday 1st March|
|Northampton 39 - 13 Gloucester|
|Exeter 18 - 0 London Irish|
|Harlequins 21 - 20 Worcester|
|Wasps 17 - 21 Sale Sharks|
|Friday 28th February|
|Bath 10 - 23 Saracens|
|Sunday 23rd February|
|Saracens 23 - 10 Exeter|
|Newcastle 16 - 22 Northampton|
|London Irish 15 - 20 Leicester|
|Saturday 22nd February|
|Worcester 12 - 24 Sale Sharks|
|Bath 32 - 25 Wasps|
|Gloucester 25 - 20 Harlequins|
|Sunday 16th February|
|Leicester 11 - 8 Gloucester|
|Saturday 15th February|
|Exeter 23 - 27 Bath|
|Wasps 20 - 23 London Irish|
|Northampton 30 - 14 Worcester|
|Harlequins 18 - 14 Newcastle|
|Friday 14th February|
|Sale Sharks 10 - 15 Saracens|
|Sunday 9th February|
|Harlequins 11 - 10 Wasps|
|Saturday 8th February|
|Exeter 16 - 17 Northampton|
|Saracens 13 - 22 London Irish|
|Bath 24 - 6 Newcastle|
|Friday 7th February|
|Sale Sharks 24 - 19 Gloucester|
|Worcester 22 - 23 Leicester|
Read the thoughts and opinions of Phil Edwards with skysports.com