South Africa forwards Chiliboy Ralepelle and Gurthro Steenkamp will return home after they were injured in the Boks' tour opener.
South Africa captain Chiliboy Ralepelle believes the team's defeat to Leicester will have taught the new players a harsh lesson.
South Africa assistant coach Dick Muir admitted the plan to blood several youngsters 'may have failed' as Leicester won 22-17.
Leicester have scored an historic 22-17 victory against South Africa in the World Champions' first match of their autumn tour.
New Leicester signing Lote Tuqiri is set to make his debut from the bench when the Tigers tackle South Africa at Welford Road.
South Africa assistant coach Dick Muir has labelled the Springboks' clash against Leicester on Friday as a "huge game".

England 9-18 Australia - Highlights
Harlequins 15-15 Llanelli - Davies
Harlequins 15-15 Llanelli - Robshaw
Harlequins 15-15 Llanelli - Owens
England 9-18 Australia - Wilkinson & Moody
England 9-18 Australia - Johnson
England 9-18 Australia - Giteau
England 9-18 Australia - Genia & Ashley-Cooper
| Time | Fixture |
|---|---|
| South Africa | |
| Friday 13th November | |
| International Match | |
| 19:45 | France vs South Africa |
| Saturday 21st November | |
| 14:00 | Italy vs South Africa |
| Saturday 28th November | |
| 14:30 | Ireland vs South Africa |
| Pos | Team | P | Pts |
|---|---|---|---|
| 1 | South Africa | 6 | 21 |
| 2 | New Zealand | 6 | 13 |
| 3 | Australia | 6 | 7 |
Ian McGeechan is set to meet up with skysports.com - and we want YOU to set the questions.
Opta takes a look at England's centre conundrum and assesses Shane Geraghty's chances.
Will Greenwood casts his eye over the latest Heineken Cup action and gives his picks of the week.