A rare goal from Kevin Strootman helped Roma reclaim second place in the Serie A table as they beat derby rivals Lazio 2-0 on Sunday.
Roma were unable to keep pace with Serie A leaders Juventus after they were held to a goalless draw at struggling Empoli.
Joe Hart was at fault for Mauro Icardi's first goal as Inter Milan beat Torino 2-1 in Serie A on Wednesday.
Frank de Boer's future as Inter Milan head coach is under serious threat after a 2-1 defeat to Atalanta in Bergamo on Sunday.
Shakhtar Donetsk maintained their 100 per cent start to Europa League Group H as they thrashed Gent 5-0.
Inter Milan were held to a 1-1 draw at home by Bologna in Serie A on Sunday after a fine volley from Ivan Perisic.