Nice remain three points clear at the top of Ligue 1 after winning 1-0 at Saint-Etienne on Sunday, as Marseille beat Caen.
Paris St Germain kept pace with Ligue 1 rivals Nice and Monaco after thrashing Rennes 4-0 at the Parc des Princes on Sunday.
Aritz Aduriz netted five goals in Athletic Bilbao's 5-3 win over Genk in the Europa League on Thursday, as Ajax, Schalke, Shakhtar and Zenit all progressed.
Monaco missed the chance to close the gap on Ligue 1 leaders Nice while Alexandre Lacazette scored twice for Lyon.
Rudi Garcia made a positive start as Marseille head coach with a 0-0 draw at Paris St-Germain in Ligue 1 on Sunday.
Shakhtar Donetsk maintained their 100 per cent start to Europa League Group H as they thrashed Gent 5-0.
Paris Saint-Germain claimed a share of second place in Ligue 1 with a 2-1 win at Nancy.
Lyon bounced back from successive defeats with victory against St Etienne, while Angers held Marseille to a 1-1 draw in Ligue 1.
Alassane Plea's goal earned Nice a 1-0 win over AS Nancy on Sunday that moves them top of Ligue 1.
Mario Balotelli scored twice as Nice beat Monaco 4-0 to go top of Ligue 1, while there were also wins for Lyon and Bordeaux.
Lyon missed the chance to climb up to third in Ligue 1 after they were held to a goalless draw against Marseille.
Robert Beric scored an injury-time leveller to deny PSG a return to the top of Ligue 1 as they were held to a 1-1 draw at home to St Etienne.
Paris Saint-Germain suffered their first league defeat since March as Monaco struck an early blow in the Ligue 1 title race.
Man Utd will face Fenerbahce, Feyenoord and Zorya Luhansk in the Europa League, while Southampton are in a group with Inter Milan.
Newcastle's out-of-favour midfielder Henri Saivet has joined Ligue 1 club Saint-Etienne on a season-long loan.
Paris Saint-Germain beat newly promoted Metz 3-0 in Unai Emery's first home game in charge on Sunday.
Bordeaux beat Saint-Etienne, while newly-promoted Metz came from behind to beat Lille. Get the latest from Ligue 1...
West Ham will play Romanian champions FC Astra Giurgiu in the Europa League play-off round.
Lyon secured a Champions League place for next season after thrashing Monaco 6-1 at Parc Olympique Lyonnais.
Lyon and Monaco made it seemingly a two-horse race for second place in Ligue 1 with wins on Saturday.