Alassane Plea's goal earned Nice a 1-0 win over AS Nancy on Sunday that moves them top of Ligue 1.
Mario Balotelli scored twice as Nice beat Monaco 4-0 to go top of Ligue 1, while there were also wins for Lyon and Bordeaux.
Lyon missed the chance to climb up to third in Ligue 1 after they were held to a goalless draw against Marseille.
Robert Beric scored an injury-time leveller to deny PSG a return to the top of Ligue 1 as they were held to a 1-1 draw at home to St Etienne.
Paris Saint-Germain suffered their first league defeat since March as Monaco struck an early blow in the Ligue 1 title race.
Man Utd will face Fenerbahce, Feyenoord and Zorya Luhansk in the Europa League, while Southampton are in a group with Inter Milan.
Newcastle's out-of-favour midfielder Henri Saivet has joined Ligue 1 club Saint-Etienne on a season-long loan.
Paris Saint-Germain beat newly promoted Metz 3-0 in Unai Emery's first home game in charge on Sunday.
Bordeaux beat Saint-Etienne, while newly-promoted Metz came from behind to beat Lille. Get the latest from Ligue 1...
West Ham will play Romanian champions FC Astra Giurgiu in the Europa League play-off round.
Lyon secured a Champions League place for next season after thrashing Monaco 6-1 at Parc Olympique Lyonnais.
Lyon and Monaco made it seemingly a two-horse race for second place in Ligue 1 with wins on Saturday.
Monaco missed the chance to return to second place in Ligue 1 after conceding a late goal to draw 1-1 at Rennes.
PSG ripped Caen to pieces in a 6-0 thrashing at the Parc des Princes, sending the champions 30 points clear in Ligue 1.
Marseille lost more ground in their bid to play in Europe next season as a 1-1 draw at Lorient extended their winless run in Ligue 1 to six games.
Ajaccio secured an important 1-1 draw against Bordeaux as they battle to stay in Ligue 1.
Paris Saint-Germain fielded a second-string side and were held 0-0 at home by Montpellier in Ligue 1 on Saturday.
Paris Saint Germain eased into the French Cup semi-finals on Wednesday thanks to a 3-1 away win at Saint Etienne.
Lyon finished with nine men in a narrow defeat at Lille, while Michy Batshuayi struck late to rescue a point for Marseille.
Nice moved into the top three in Ligue 1 despite being held to a 1-1 home draw by Marseille on Sunday.