Barcelona kept up their stunning form in Spain while David Beckham made his Serie A debut.
Hearts knocked Edinburgh rivals Hibernian out of the Scottish Cup and in France, Bordeaux closed the gap on leaders Lyon to one point.
Barcelona continued their relentless march towards the title with a sixth successive victory. Pep Guardiola's side came from behind to beat Osasuna 3-2, with Samuel Eto'o, Xavi and Lionel Messi on the scoresheet.
Arjen Robben, Raul and Sergio Ramos found the target as Real Madrid crushed Real Mallorca 3-0 to move second.
Valencia and Villarreal shared six goals in a thriller on Saturday and Sevilla defeated Deportivo La Coruna 3-1.
Beckham, on loan from Los Angeles Galaxy, was a surprise starter as AC Milan drew 2-2 at Roma, with Alexandre Pato netting a brace for the Rossoneri and Mirko Vucinic scoring both of the home side's goals.
Also on Sunday, Juventus moved to within four points of leaders Inter Milan as Alessandro Del Piero's free-kick gave them victory over Siena.
Inter had been held to a surprise 1-1 draw by Cagliari on Saturday, with Zlatan Ibrahimovic's strike cancelling out Robert Acquafresca's opener.
Hearts beat 10-man Hibs 2-0 thanks to goals from Christian Nade and Gary Glen, while Dundee United also moved into the fifth round with an emphatic 4-0 win against East Stirlingshire.
Celtic stayed on course for a domestic double as they came from behind to see off Dundee 2-1. Aberdeen, Hamilton, Inverness and Falkirk also advanced in the competition.
Lyon could only play out a 1-1 draw with Lorient, while in-form Rennes claimed a narrow 1-0 victory over Grenoble.
Bordeaux took advantage of Lyon's dropped points on Sunday as they thumped Paris St Germain 4-0. Souleymane Diawara, Fernando Cavenaghi, Yoann Gourcuff and Fernando Menegazzo grabbed the goals.
Porto slipped from first to third in Portugal as they were held to a goalless draw by Trofense. Benfica and Sporting Lisbon occupy the top two spots after wins over Braga and Maritimo respectively.
Europe's other top leagues remain on winter break. The Eredivisie resumes on Friday but the Bundesliga is not back until the end of the month.

Latest Sky Sports News Report
Chelsea 1-0 Man Utd - Ferguson
Chelsea 1-0 Man Utd - Ancelotti
West Ham 1-2 Everton - Zola
West Ham 1-2 Everton - Moyes
Wigan 1-1 Fulham - Martinez
Wigan 1-1 Fulham - Hodgson
Hull 2-1 Stoke - Horton
| Time | Fixture |
|---|---|
| Sunday 8th November | |
| Barclays Premier League | |
| 13:30 | Hull vs Stoke |
| 15:00 | West Ham vs Everton |
| 15:00 | Wigan vs Fulham |
| 16:00 | Chelsea vs Man Utd |
| Monday 9th November | |
| Barclays Premier League | |
| 20:00 | Liverpool vs Birmingham |
| Saturday 21st November | |
| Barclays Premier League | |
| 12:45 | Liverpool vs Man City |
| 15:00 | Birmingham vs Fulham |
| 15:00 | Burnley vs Aston Villa |
| 15:00 | Chelsea vs Wolverhampton |
| 15:00 | Hull vs West Ham |
| 15:00 | Sunderland vs Arsenal |
| 17:30 | Man Utd vs Everton |
| Sunday 22nd November | |
| Barclays Premier League | |
| 13:30 | Bolton vs Blackburn |
| 15:00 | Tottenham vs Wigan |
| 16:00 | Stoke vs Portsmouth |
| Wednesday 25th November | |
| Barclays Premier League | |
| 19:45 | Hull vs Everton |
| 20:00 | Fulham vs Blackburn |
| Saturday 28th November | |
| Barclays Premier League | |
| 15:00 | Blackburn vs Stoke |
| 15:00 | Fulham vs Bolton |
| 15:00 | Man City vs Hull |
| Time | Result |
|---|---|
| Saturday 7th November | |
| Barclays Premier League | |
| Wolverhampton 1 - 4 Arsenal | |
| Man City 3 - 3 Burnley | |
| Tottenham 2 - 0 Sunderland | |
| Blackburn 3 - 1 Portsmouth | |
| Aston Villa 5 - 1 Bolton | |
| Wednesday 4th November | |
| Barclays Premier League | |
| West Ham 2 - 1 Aston Villa | |
| Sunday 1st November | |
| Barclays Premier League | |
| Birmingham 0 - 0 Man City | |
| Saturday 31st October | |
| Barclays Premier League | |
| Man Utd 2 - 0 Blackburn | |
| Sunderland 2 - 2 West Ham | |
| Portsmouth 4 - 0 Wigan | |
| Bolton 0 - 4 Chelsea | |
| Stoke 2 - 2 Wolverhampton | |
| Fulham 3 - 1 Liverpool | |
| Burnley 2 - 0 Hull | |
| Everton 1 - 1 Aston Villa | |
| Arsenal 3 - 0 Tottenham | |
| Sunday 25th October | |
| Barclays Premier League | |
| West Ham 2 - 2 Arsenal | |
| Man City 2 - 2 Fulham | |
| Liverpool 2 - 0 Man Utd | |
| Bolton 3 - 2 Everton | |
Skysports.com looks at the best and worst moments from the latest round of top-flight fixtures.
Have a read through the skysports.com debate on Chelsea's 1-0 win over Man Utd at Stamford Bridge.
Pictures from Sunday's Premier League action where Hull snatch victory and Chelsea beat Man United.
Sir Alex Ferguson insisted John Terry's winner should not have been allowed to stand after Man United's defeat at Chelsea.
A John Terry header proved the difference as Chelsea beat Manchester United to move clear at the top of the Premier League.
Carlo Ancelotti admitted his delight in beating Chelsea's "best opponent" at Stamford Bridge.
Wes Brown feels Chelsea's winning goal should not have stood as he insists he was fouled by Didier Drogba.
Darren Bent is in the England squad to face Brazil, while Stephen Warnock and Tom Huddlestone have also been called up.