Fernando Torres is a major doubt to face his former club Atletico Madrid in the UEFA Champions League next week.
The Liverpool striker limped out of Spain's win in Belgium after just 16 minutes and was visibly upset.
The injury is to his right leg with conflicting reports in Spain about whether it is his hamstring or thigh. If it is the former, then it may be the same injury he sustained against Aston Villa earlier in the season which saw him ruled out for two weeks.
Initial reports in Spain suggest that the injury, although not serious, is likely to sideline him for 10 days - which would rule him out of Saturday's home meeting with Wigan in the Premier League and the return to Atletico, his former club.
Spain boss Vicente del Bosque admitted Torres was upset with the injury.
"I am very sad for Torres," he said. "This is undoubtedly a very big blow for him."
Spain team doctor Oscar Celada confirmed Torres left the field in some distress.
"He has intense pain in the back part of the thigh," said Celada.
"It is difficult to diagnose now exactly the extent, if it is a question of a strain or a small tear.
"If it is a strain then he could be out for about a week."
Torres' Liverpool team-mates Xabi Alonso and Alvaro Arbeloa admitted losing the striker, who has started the new Premier League season in fine style, is a big blow.
"For us it is undoubtedly bad news for both the international squad and Liverpool," said Alonso.
"We have to wait and see what the tests say, but we do not stop now until around Christmas, and we have a big calendar coming up with Atletico Madrid and Chelsea, and we cannot let up.
"It is not the first time this has happened for him with the national side, and it is a blow to have an injury when he is in such a good streak of form."
Arbeloa added: "It is bad news to have a new muscle injury at a time like this.
"We hope it is nothing too serious and hope he will soon be playing for Liverpool because he is very important."
Torres is now almost certainly out of the weekend Premier League clash with Wigan at Anfield, but it remains be seen whether he has enough time to recover for the Atletico clash.
Further bad news for Liverpool boss Rafa Benitez came from Scandinavia as Ryan Babel limped out of Holland's win against Norway after just 26 minutes.
As yet the Dutch authorities have not confirmed the extent of the injury to the forward.

Lyon 1-1 Liverpool
Champions League round up - Nov 4th
Lyon 1-1 Liverpool - Benitez
Benitez explains Torres situation
Fulham 3-1 Liverpool - Hodgson
Fulham 3-1 Liverpool - Benitez
Fulham 3-1 Liverpool - Nicholas
Arsenal 2-1 Liverpool - Benitez
| Time | Fixture |
|---|---|
| Monday 9th November | |
| Barclays Premier League | |
| 20:00 | Liverpool vs Birmingham |
| Saturday 21st November | |
| Barclays Premier League | |
| 12:45 | Liverpool vs Man City |
| Tuesday 24th November | |
| UEFA Champions League | |
| 19:45 | Debrecen vs Liverpool |
| Sunday 29th November | |
| Barclays Premier League | |
| 13:30 | Everton vs Liverpool |
| Saturday 5th December | |
| Barclays Premier League | |
| 15:00 | Blackburn vs Liverpool |
| Wednesday 9th December | |
| UEFA Champions League | |
| 19:45 | Liverpool vs Fiorentina |
| Sunday 13th December | |
| Barclays Premier League | |
| 16:00 | Liverpool vs Arsenal |
| Wednesday 16th December | |
| Barclays Premier League | |
| 20:00 | Liverpool vs Wigan |
| Saturday 19th December | |
| Barclays Premier League | |
| 12:45 | Portsmouth vs Liverpool |
| Saturday 26th December | |
| Barclays Premier League | |
| 17:30 | Liverpool vs Wolverhampton |
| Tuesday 29th December | |
| Barclays Premier League | |
| 19:45 | Aston Villa vs Liverpool |
| Sunday 10th January | |
| Barclays Premier League | |
| 16:00 | Liverpool vs Tottenham |
| Saturday 16th January | |
| Barclays Premier League | |
| 12:45 | Stoke vs Liverpool |
| Tuesday 26th January | |
| Barclays Premier League | |
| 19:45 | Wolverhampton vs Liverpool |
| Saturday 30th January | |
| Barclays Premier League | |
| 15:00 | Liverpool vs Bolton |
| Saturday 6th February | |
| Barclays Premier League | |
| 15:00 | Liverpool vs Everton |
| Tuesday 9th February | |
| Barclays Premier League | |
| 19:45 | Arsenal vs Liverpool |
| Time | Result |
|---|---|
| Wednesday 4th November | |
| UEFA Champions League | |
| Lyon 1 - 1 Liverpool | |
| Saturday 31st October | |
| Barclays Premier League | |
| Fulham 3 - 1 Liverpool | |
| Wednesday 28th October | |
| Carling Cup | |
| Arsenal 2 - 1 Liverpool | |
| Sunday 25th October | |
| Barclays Premier League | |
| Liverpool 2 - 0 Man Utd | |
| Tuesday 20th October | |
| UEFA Champions League | |
| Liverpool 1 - 2 Lyon | |
| Saturday 17th October | |
| Barclays Premier League | |
| Sunderland 1 - 0 Liverpool | |
| Sunday 4th October | |
| Barclays Premier League | |
| Chelsea 2 - 0 Liverpool | |
| Tuesday 29th September | |
| UEFA Champions League | |
| Fiorentina 2 - 0 Liverpool | |
| Saturday 26th September | |
| Barclays Premier League | |
| Liverpool 6 - 1 Hull | |
| Tuesday 22nd September | |
| Carling Cup | |
| Leeds 0 - 1 Liverpool | |
| Saturday 19th September | |
| Barclays Premier League | |
| West Ham 2 - 3 Liverpool | |
| Wednesday 16th September | |
| UEFA Champions League | |
| Liverpool 1 - 0 Debrecen | |
| Saturday 12th September | |
| Barclays Premier League | |
| Liverpool 4 - 0 Burnley | |
| Saturday 29th August | |
| Barclays Premier League | |
| Bolton 2 - 3 Liverpool | |
| Monday 24th August | |
| Barclays Premier League | |
| Liverpool 1 - 3 Aston Villa | |
| Wednesday 19th August | |
| Barclays Premier League | |
| Liverpool 4 - 0 Stoke | |
| Sunday 16th August | |
| Barclays Premier League | |
| Tottenham 2 - 1 Liverpool | |
| Saturday 8th August | |
| Friendly Match | |
| Liverpool 1 - 2 Atletico Madrid | |
| Wednesday 5th August | |
| Friendly Match | |
| Lyn Oslo 0 - 2 Liverpool | |
| Sunday 2nd August | |
| Friendly Match | |
| Espanyol 3 - 0 Liverpool | |
| Pos | Team | P | Pts |
|---|---|---|---|
| 5 | Aston Villa | 12 | 21 |
| 6 | Manchester City | 11 | 20 |
| 7 | Liverpool | 11 | 18 |
| 8 | Sunderland | 12 | 17 |
| 9 | Stoke City | 11 | 16 |
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Liverpool's David Ngog wants to score more goals for Rafa Benitez to repay the Spaniard for improving his game.
Liverpool striker Fernando Torres has been to Valencia to have a second opinion on his troublesome groin injury.
Daniel Agger says Liverpool must rediscover their killer instinct against Birmingham.