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Defeat to old club Everton might be the most damning yet for the United boss, writes Daniel Storey.
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Bayern Munich are still without a win in the new Bundesliga season after they lost 2-1 at Mainz.
Both sides went into the game at the Bruchweg Stadion off the back of draws in their opening two games.
And it was Mainz who registered their first win. The home side were 2-0 up at the break as Andreas Ivanshitz (25) and Aristide Bance (37) fired home.
Nikolce Noveski's own goal just after the break gave Bayern some hope, but Louis van Gaal's men could not find an equaliser.
Bayer Leverkusen moved to the top of the table on goal difference after a resounding 5-0 win at Freiburg.
Stefan Kiessling opened the scoring after 36 minutes, before Bayer powered their way to victory in the second half.
Tranquillo Barnetta (47 & 75) and Eren Derdiyok (70 & 84) both grabbed braces to seal a comprehensive victory.
Borussia Dortmund and Stuttgart are both on four points after three games following their 1-1 draw at the Signal Iduna Park.
Borussia took the lead on the half-hour mark through Nelson Valdez, but Stuttgart secured a share of the spoils thanks to Georg Niedermaier's second-half efffot.
Hannover grabbed their opening victory of the season with Jiri Stajner claiming a goal in each half to secure a 2-0 victory at winless Nurnberg.
Finally, Cologne were held to a goalless draw at home by Eintracht Frankfurt.
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Bayer Leverkusen's general manager Wolfgang Holzhauser has criticised the sale of Marian Sarr to Borussia Dortmund.
Bayer Leverkusen have confirmed that midfielder Renato Augusto will be leaving the club this winter to return to Brazil.
Borussia Dortmund, Stuttgart, Wolfsburg and Bochum all progressed to the quarter-finals of the German Cup.
Bayern Munich reached the DFB-Pokal fourth round after a 2-0 win at Augsburg, despite playing 42 minutes with 10 men.
Schalke host Mainz in the DFB-Pokal third round on Tuesday, Bayern Munich host Augsburg and there are six other ties.