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Arsenal captain Cesc Fabregas has pulled out of Spain's friendly against Colombia with a stomach bug.
The midfielder was due to travel to Madrid with the national team for the game at the Santiago Bernabeu on Wednesday, but is now remaining in London.
Fabregas played the full 90 minutes of Arsenal's 4-4 thriller with Newcastle on Saturday, but consultations with club doctors have revealed him to be suffering from gastroenteritis.
Vicente del Bosque has opted not to select a replacement for Fabregas, with the coach likely to stick with first-choice pairing Xavi and Andres Iniesta in the centre of the park.
It is not yet clear how long the 23-year-old will take to recover, leaving his participation in Arsenal's match at home to Wolves on Saturday still in some doubt.
Fabregas has won 58 caps for the World Cup and European Championship holders, scoring six goals so far in his international career.
thank you gastroenteritis. these interntl friendlies are a worrying tym coz we always loose players to them and rarely get compensated.
Posted 16:00 7th February 2011
Good! Van Persie out with flu, now Cesc with stomach bug. We're learning very fast. It's always been Man-U and Chelsea players withdrawing from friendly intl's with mystery injuries only to be fit for the next league fixtures!
Posted 14:47 7th February 2011
Great to see Fab and RVP showing their commitment to the Arsenal by sicking out of these meaningless international injury-fests.
Posted 14:40 7th February 2011
The midweek friendlies dominate the World Cup build-up as several of the main contenders struggled.
Who impressed me at Wembley on Wednesday night? Well, not the manager - and I do like Roy Hodgson.
Sky Sports News' England reporter Nick Collins names the 23 men, as it stands, who he thinks will be in Roy Hodgson's England squad this summer.
Read the thoughts and opinions of Jamie Carragher with skysports.com
Spain coach Vicente del Bosque felt his side's ball retention gave Panama little chance to cause a surprise.
Spain cruised to a 5-1 win over Panama thanks in part to two goals from Barcelona forward Pedro.
Michu's red-hot form since arriving in the Premier League is set to be rewarded with a first Spain call-up.
Andres Iniesta believes Spain and Barcelona have proven that talent can come out on top over physicality.
Chelsea striker Juan Mata has been included in the Spain squad for next week's friendly in Panama.