Top seed Elena Dementieva fell to a 6-0 3-6 7-6 (7-4) defeat to Virginie Razzano on Wednesday that saw her exit the AEGON International in Eastbourne at the second round stage.
The world number four got off to a disastrous start and, despite breaking early in the second set to obtain a foothold in the match she went down to the Frenchwoman in a third set tie-break.
Razzano will now face eighth seed and defending champion Agnieszka Radwanska, who was the beneficiary of AEGON Classic winner Li Na's retirement when 1-3 down in the opening set.
French Open semi-finalist Samantha Stosur could not repeat her Paris form as she lost 6-1 5-7 6-1 to Danish sixth seed Caroline Wozniacki.
Qualifier Ekaterina Makarova will be Wozniacki's opponent in the quarter-finals after winning two titanic tie-breaks to claim a 7-6 (10-8) 7-6 (15-13) victory against former Wimbledon champion Amelie Mauresmo.
Another qualifier, Vera Dushevina, progressed when her opponent, seventh seed Nadia Petrova, pulled out with a back injury leading 7-5 0-1.
Dushevina will meet Canada's Aleksandra Wozniak, a 7-6 (7-3) 6-3 winner against Zheng Jie, while former Wimbledon runner-up Marion Bartoli beat Anna Chakvetadze 7-5 6-3.
The final last-eight spot went to Spain's Anabel Medina Garrigues, who let slip a 5-0 lead in the second set but recovered to win 6-1 7-5.
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