Last updated: 15th September 2008
A late two-point conversion play from the Denver Broncos saw them grab a dramatic 38-39 victory over the still winless San Diego Chargers at Mile High stadium.
Also struggling so far are the Seattle Seahawks as their injury-hit team went down to a shock home defeat against the 49ers in overtime, while Matt Cassel started his task of filling in for Tom Brady by defeating Brett Favre and the Jets.
The New York Giants continued their dominance on the road to maintain their perfect start to the season while Buffalo, Carolina, Tennessee and Green Bay also moved to 2-0 for the season.
Meanwhile, the Indianapolis Colts rallied from a 15-point deficit to defeat the Minnesota Vikings 18-15, Adam Vinatieri landing a 47-yard field goal with just three seconds remaining.
Eli Manning threw three touchdown passes in the Giants' emphatic 41-13 victory over St Louis Rams as the New Yorkers recorded their 12th consecutive road triumph.
Rookie James Hardy hung on to a late seven-yard touchdown pass to earn Buffalo the spoils against Jacksonville, while Jonathan Stewart rushed for two TDs to inspire Carolina to a narrow 20-17 home win over the Chicago Bears.
Pittsburgh's stingy defence did the trick again in a low socring victory over Cleveland, but Miami were far more welcoming to Arizona QB Kurt Warner and receiver Anquan Boldin as they combined for three TDs in an emphatic win for the Cardinals.
Mike Shanahan took a chance and a late two-point conversion did the trick as the Broncos continued their winning start to the season to stun the Chargers again in a thriller.
San Diego have now lost both their opening games of the season in the dying seconds of the match, with Jay Cutler hitting Eddie Royal for the late TD and then the two-pointer to win the game.
Just two plays earlier Cutler had fumbled but a bad call from the officials overruled it and the Broncos took the lucky break to win a real humdinger.
Cutler threw four TD passes, two to tight end Tony Scheffler, while Phillip Rivers hit Chris Chambers for two of his three TD passes as both QBs went over 350 yards.
More injuries hit Seattle as 49ers QB JT O'Sullivan enjoyed a 300-yard passing game and kicker Joe Nedney recovered from a missed field goal late in regulation to nail one in overtime for the win.
Seahawks quarterback Matt Hasselbeck is now without his top six receivers and he threw three interceptions, one of which was returned 86 yards for a touchdown by Patrick Willis
O'Sullivan was sacked eight times as the Mike Martz-inspired 49ers offence left him wide open, but he dragged himself off the floor to respond with 321 yards and on TD throw.
Matt Cassel started the big task of replacing Tom, Brady for the season in good style with an efficient if unspectacular display to defeat Brett Favre and the Jets.
Cassel threw for 165 yards in total while Sammy Morris scored a one-yard touchdown and importantly Stephen Gostkowski kicked four field goals to win it for the Patriots.
It was a 21st consecutive regular season win for the Pats and an eighth straight at the home of the Jets, with Favre's first interception of the season a crucial point of the match.
Kurt Warner rolled back the years as he led the Cardinals to a 2-0 start for the first time in 17 years as they destroyed the Dolphins for their 11th straight road defeat.
37-year-old Warner threw for 361 yards and three TDs, all to Anquan Boldin, as he joined Peyton Manning in an NFL record third perfect passer rating of 158.3.
Larry Fitzgerland and Boldin both had 100-yard games as they caught six passes each as Warner took to the skies and Maimi had no answer.
The result was never in doubt in Cleveland if history is anything to go by as the Steelers extended the longest winning streak running in the NFL with a tenth straight defeat of the Browns.
Despite the gusty winds Ben Roethlisberger found Hines Ward for the winning TD and the tough Steelers defence did the rest for a 2-0 start to the season.
The Falcons and rookie quarterback Matt Ryan were brought back down to earth after a memorable opening win as Brian Griese looked to have sealed the starting job for the Bucs with a solid win.
With the Tampa Bay defence shackling Michael Turner, Griese hit James Gilmore with a five-yard pass for the opening TD, which was added to by Warrick Dunn's 17-yard run and Earnest Graham's game-sealing 68-yarder.
Jonathan Stewart rushed for two touchdowns as Carolina came from 17-3 down to defeat the Chicago Bears.
The Bears looked to be on course for a second straight road win when Jason McKie scored on a one-yard run following an interception by Charles Tillman early in the third quarter.
But having generated a turnover of their own, the Panthers got themselves back in the contest when Stewart eventually crashed over from four yards.
Stewart then claimed the winning score as he went over from a yard out midway through the fourth quarter after Jake Delhomme led the Panthers on a 55-yard drive.
Back-up quarterback Kerry Collins proved an able deputy for the injured Vince Young, helping unbeaten Tennessee topple Cincinnati.
The former Oakland Raider threw an 11-yard touchdown pass to Justin Gage after the Titans had scored in the first quarter through Lendale White's close range run.
In between the Bengals levelled matters on a 13-yard run by running back Chris Perry, though once again their high-powered offence struggled.
They failed to score a single point in the second half, the Titans adding to their tally with a field goal from Rob Bironas before sealing the win when linebacker Keith Bulluck recovered a blocked punt in the end zone.
Detroit were left to rue late interceptions as Green Bay held off a strong fightback from the Lions to clinch an ultimately flattering 48-25 victory.
Lions quarterback Jon Kitna was picked off three times in the fourth quarter - two of which were returned for touchdowns - as the Packers maintained their perfect start.
Having found themselves 21-0 in arrears, Detroit had responded strongly and at one stage led 25-24.
Packers QB Aaron Rodgers produced a superb first-half showing, throwing touchdown passes to James Jones, Donald Driver and Jordy Nelson as Green Bay took charge.
But Kitna edged his side ahead as he found Calvin Johnson from 47 yards with a little over five minutes left, but then imploded allowing Brandon Jackson and Charles Woodson to return touchdowns as Green Bay racked up 24 points in the closing stages.
The Buffalo Bills are 2-0 at the start of the new season after overcoming the highly-fancied Jacksonville Jaguars on the road.
Quarterback Trent Edwards finished 20-of-25 for 239 yards and a touchdown, which came courtesy of a spectacular catch from rookie receiver James Hardy.
That score put the Bills ahead for the first time in the second half and a Rian Lindell field goal in the final minute made sure of the victory.
With an injury-hit offensive line hampering their progress, the Jaguars managed just one touchdown courtesy of two-yard run by Maurice Jones-Drew. All the rest of their points came from the boot of kicker Josh Scobee.
Rookie Darren McFadden scored his first NFL touchdown as the Oakland Raiders overcame the Kansas City Chiefs 23-8.
Running back McFadden carried the ball 21 times for 164 yards, including a 50-yard burst to set up the Raiders' first rushing touchdown of year.
The youngster then capped an excellent display with a 19-yard touchdown run in the third quarter to ensure Oakland bounced back from last week's defeat.
Sebastian Janikowski kicked three field-goals while Michael Bush also got on the scoresheet with a 32-yard touchdown run.
Tony Gonzalez held on to a two-yard touchdown pass from Tyler Thigpen late in the fourth quarter for the Chiefs' only score.
The Colts were forced to come from 15 points down to sneak past the Minnesota Vikings and register their first win of the season.
The Vikings repeatedly stalled when in scoring positions but still built up a healthy lead courtesy of Ryan Longwell's five field goals.
The Colts finally got on the board on Joseph Addai's one-yard touchdown run late in the third quarter and Peyton Manning then hit Reggie Wayne for a 32-yard touchdown with 6:01 left.
Dominic Rhodes tied up the match with a two-point conversion run before Adam Vinatieri settled the contest with just three seconds remaining with a 47-yard field-goal.
The New York Giants notched a 12th consecutive road win as they crushed the St Louis Rams 41-13 on Sunday.
Quarterback Eli Manning threw three touchdown passes while the Giants' defence snuffed out a ragged Rams outfit in a one-side contest.
After his rather erratic display against Washington last week, Manning silenced his critics with a superb showing, completing 20-of-29 passes for 260 yards.
He edged the Giants ahead for the first time on their second possession when he found Plaxico Burress for a 33-yard touchdown and from that point the Giants did not look back.
Manning also threw a 10-yard scoring strike to Amani Toomer in the third quarter and an 18-yard TD to Ahmad Bradshaw with 7:18 remaining as the Rams were routed for a second week running following their heavy loss to Philadelphia.
Giants defensive end Justin Tuck recorded two sacks and returned an interception 41 yards for a TD to lead New York, who sacked Marc Bulger six times and limited St Louis to just 201 yards of total offence.
Rookie coach Jim Zorn got his first win as the Washington Redskins' head coach at the second attempt as his side rallied to stun New Orleans.
The Saints appeared to be on their way to a 2-0 record for the new season when Reggie Bush's 55-yard punt return put them 24-15 ahead with just one quarter to play.
They had managed two touchdowns in the first half - one of which was a first in the NFL for receiver Robert Meachem - as well as a field goal from Martin Gramatica.
However the Redskins climbed off the canvas to get the victory, quarterback Jason Campbell - who finished 24-of-36 for 321 yards - throwing a scoring pass to Santana Moss after Clinton Portis had run in for his second touchdown of the game.
KC is siding with the Chargers as they battle the Raiders to avoid the tag of the worst team in California.
KC expects Houston to make home advantage count when they take on the equally-troubled Jags on Monday.
The play-off picture is beginning to become clearer in the NFL after another action-packed round of games.