Casey: Irish leader
London Irish will be going all out to beat defending champions Ospreys and hope results go their way to make the EDF Energy Cup semi-finals.
Bob Casey leads a strong London Irish side at the Madejski on Sunday which knows that even a win leaves them still sweating on the result of Harlequins' trip to Worcester.
Only a win over Welsh side Ospreys and a Quins victory at Sixways will help the Exiles into the semi-finals of the competition.
"We will be going out against the Ospreys to win, without question," said coach Toby Booth.
"The Ospreys are among the most talented teams in these islands as their position at the top of the Magners League testifies."
Booth is able to name a strong side to take on the Magners League front runners though, with eleven full internationals in his starting XV for the game.
An experienced bench will also back-up the starting side, with the likes of Mike Catt and Peter Richards able to come on during the contest.
The Ospreys also have a strong side despite the on-giong feud with the Welsh Rugby Union over player availability for internationals.
Wales starters Gavin Henson, Shane Williams and James Hook are all in the Ospreys XV in the backs, with Ian Evans, Ian Gough, Adam Jones and Huw Bennett starting in the pack.
Ryan Jones has also been named amongst the replacements alongside three other members of the Wales squad, a move which will not go down well with the WRU.
London Irish go into the game on the back of a three-game winning streak, but have not beaten a Welsh side in the EDF Energy Cup since 2005.
For their part, the Ospreys are in even better form with four wins out of their last five games in all competitions and have won their last seven in the competition they won last year.
London Irish: 15 Peter Hewat, 14 Topsy Ojo, 13 Elvis Seveali'i, 12 Seilala Mapusua, 11 Sailosi Tagicakibau, 10 Shane Geraghty, 9 Paul Hodgson, 8 Chris Hala'Ufia, 7 Steffon Armitage, 6 Richard Thorpe, 5 Bob Casey, 4 James Hudson, 3 Faan Rautenbach, 2 David Paice, 1 Clarke Dermody.
Replacements: 16 Tonga Lea'aetoa, 17 James Buckland, 18 Kieran Roche, 19 Declan Danaher, 20 James Bailey, 21 Peter Richards, 22 Mike Catt.
Ospreys: 15 Jonny Vaughton, 14 Nikki Walker, 13 Tommy Bowe, 12 Gavin Henson, 11 Shane Williams, 10 James Hook, 9 Jamie Nutbrown, 8 Filo Tiatia, 7 Marty Holah, 6 Tom Smith, 5 Ian Evans, 4 Ian Gough, 3 Adam Jones, 2 Huw Bennett, 1 Paul James (c).
Replacements: 16 Richard Hibbard, 17 Craig Mitchell, 18 Lyndon Bateman, 19 Ryan Jones, 20 Rhys Webb, 21 Dan Biggar, 22 Andrew Bishop.

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| Time | Fixture |
|---|---|
| Guinness Premiership | |
| Sunday 22nd November | |
| Guinness Premiership | |
| 15:00 | London Irish vs Newcastle |
| 15:00 | Leeds Carnegie vs Sale |
| 15:00 | Saracens vs Wasps |
| Friday 27th November | |
| 19:45 | Sale vs Wasps |
| 20:00 | Newcastle vs Northampton |
| 20:00 | Worcester vs Saracens |
| Saturday 28th November | |
| 15:00 | Harlequins vs Gloucester |
| 15:00 | Leicester vs Leeds Carnegie |
| 17:35 | Bath vs London Irish |
| Saturday 5th December | |
| 15:00 | London Irish vs Worcester |
| 15:00 | Gloucester vs Newcastle |
| 15:00 | Northampton vs Bath |
| 17:35 | Saracens vs Sale |
| Sunday 6th December | |
| 15:00 | Wasps vs Leicester |
| Saturday 26th December | |
| 14:15 | Bath vs Gloucester |
| 15:00 | Leicester vs Sale |
| 15:00 | Worcester vs Northampton |
| Sunday 27th December | |
| 15:00 | London Irish vs Saracens |
| 15:00 | Newcastle vs Leeds Carnegie |
| 16:00 | Harlequins vs Wasps |
| Friday 1st January | |
| 15:00 | Sale vs Harlequins |
| 15:00 | Saracens vs Leicester |
| Saturday 2nd January | |
| 15:00 | Northampton vs London Irish |
| 15:00 | Leeds Carnegie vs Bath |
| 15:00 | Gloucester vs Worcester |
| Result |
|---|
| Guinness Premiership |
| Saturday 21st November |
| Guinness Premiership |
| Northampton 26 - 17 Harlequins |
| Friday 20th November |
| Worcester 12 - 12 Bath |
| Gloucester 12 - 9 Leicester |
| Sunday 1st November |
| Newcastle 14 - 3 Worcester |
| Wasps 9 - 15 Leeds Carnegie |
| Saturday 31st October |
| Leicester 29 - 15 Northampton |
| Harlequins 9 - 9 London Irish |
| Bath 11 - 12 Saracens |
| Friday 30th October |
| Sale 28 - 23 Gloucester |
| Sunday 25th October |
| Saracens 21 - 15 Leeds Carnegie |
| Saturday 24th October |
| Gloucester 6 - 35 Wasps |
| London Irish 18 - 12 Leicester |
| Northampton 21 - 16 Sale |
| Worcester 22 - 26 Harlequins |
| Bath 16 - 27 Newcastle |
| Sunday 4th October |
| Leeds Carnegie 10 - 26 Gloucester |
| Wasps 20 - 15 Northampton |
| Newcastle 15 - 22 Saracens |
| Saturday 3rd October |
| Harlequins 13 - 11 Bath |
| Leicester 19 - 14 Worcester |
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