The Spaniard captured her maiden major crown at Roland Garros in June where she beat Serena Williams in the final.
However, since lifting the trophy in Paris, it's been something of a struggle for Muguruza.
An early loss at Wimbledon - where she made the final in 2015 - was followed by a heavy defeat at the Olympics.
A semi-final run in Cincinnati, where she lost to eventual champion Karolina Pliskova, was more encouraging but the Venezuela-born star has only won one match in three previous visits to Flushing Meadows.
For a player with the talent Muguruza possesses, that is a record which will surely change at some point, although whether it will be in 2016 remains open to question.