The world No 1 heads to Flushing Meadows following his third-round defeat by big-serving American Sam Querrey at SW19, which ended his chances of becoming the first man since Rod Laver in 1969 to win all four majors in a calendar year.
Djokovic did hold all four majors at once following his success at the French Open in June, and will head to the US Open as the strong favourite yet again - having beaten Roger Federer in the final last year.
The Serb's biggest competition in New York is likely to be Wimbledon champion Andy Murray, who beat Djokovic in 2012 over five sets to win his first Grand Slam title.
Despite the setback in London, Djokovic bounced back superbly with victory at the Rogers Cup in Canada, and still has six of the last nine Grand Slam titles to his name.
He will be chasing a third US Open title, having won previously in 2011 and last year, and will also be aiming to win three of the four slams in a calendar year for the third time (which he did in 2011 and 2015).