The Argentinian has been hampered by injuries throughout his career, but he's a player the higher seeds will want to avoid come the US Open.
The surprise former champion at Flushing Meadows in 2009, where he defeated both Rafael Nadal and Roger Federer en route to the title, remains a popular figure on the tennis circuit among fans and players alike.
Del Potro, ranked in the world's top-30, lost in the second round at Wimbledon earlier in the summer and will be hoping to improve on his best finish at a Grand Slam this year which came with a run to the third round of the French Open.
The Argentinian made a successful return, after a four-year absence from the ATP World Tour Masters 1000 tournament in Cincinnati with a impressive performance against Czech 10th seed Tomas Berdych in the opening round.
Del Potro, who won the Davis Cup last year, will believe he has the artillery to trouble the best in New York and will be buoyed by the knowledge that several high profile players will be missing through injury.