The Swiss star has won a major in each of the last three years with victory over Novak Djokovic at Flushing Meadow in September going with the French Open in 2015 and the Australian Open in 2014.
It was in Melbourne that the Swiss made his major breakthrough, beating Rafael Nadal in four sets to claim the title three years ago and whatever his form the 31-year-old is a dangerous opponent.
A fourth round defeat to Milos Raonic ended his bid for a second Australian crown last year but with four titles his tally was only bettered by Djokovic (5) and Andy Murray (7) and his unpredictable nature make him a major threat.
Despite the obvious high in New York, his title defence at Roland Garros was ended by Andy Murray in the semi-finals, he suffered second round defeat at Wimbledon and made only one Masters 1000 semi-final.
He was eliminated in the group stage at the World Tour Finals but his fearsome backhand and ability to raise his game make him a contender for major number four.