Defending champion Angelique Kerber will be looking to rediscover the form which saw her capture the world No 1 position at the US Open last year, having struggled to reproduce her stunning 2016 so far.
Kerber won the Australian Open and reached the Wimbledon final en route to claiming top spot with her maiden triumph at Flushing Meadows last year, but is yet to claim another title since.
Indeed, her poor form in 2017 has seen her only face one top-10 player so far, a straight-sets loss to Johanna Konta in Eastbourne, while a final loss to Anastasia Pavlyuchenkova in Monterrey represents her best run.
A round-of-16 loss to 934th-ranked Sloane Stephens in Toronto was followed by a three-set defeat to Ekaterina Makarova at the same stage in Cincinnati, offering little to suggest she's set to turn the corner in New York.
Such form is reflected by hefty price, with several players hunting their first Grand Slam shorter odds than the two-time major champion.