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Djokovic is one generally seen as the only player outside the top two with a genuine chance of glory in the fortnight in Paris.
The 22-year-old and US Open winner Juan Martin Del Potro are the only members on the tour other than Roger Federer and Rafael Nadal to clinch a major since the 2005 Australian Open.
Djokovic broke the Federer/Nadal duopoly in the Grand Slams on the hardcourts of Melbourne two years ago but the right-hander, who possesses one of the most lethal two-handed backhands in the sport, also has the all-court game to trouble the best in the business on any surface.
The world number three's pedigree on the clay is impressive, having won four titles on the red earth including the Rome Masters last season, although 'Nole' has not enjoyed the ideal preparation for the second slam of the year.
After disappointing defeats to Fernando Verdasco in Monte Carlo and Barcelona, Djokovic was forced to retire from his hometown tournament in Belgrade with breathing difficulties which then saw him miss the Madrid Open.
The Serb's health has plagued him in the past and it looks likely to determine how successful his 2010 French Open will be.
An improvement on last season's third-round exit looks likely but a route beyond the last four needs favours from lesser lights, if he is to have a hope of landing the Coupe des Mousquetaires.
French Open winner Rafael Nadal will feel unbeatable going into this year's Wimbledon, says Barry Cowan.
Barry Cowan gives his thoughts on how the French Open will pan out, from the quarter-finals onwards...