Las Palmas ended 10-man Villarreal's winning run thanks to Kevin Prince Boateng's strike in a 1-0 success.
Villarreal closed the gap back on the top four in La Liga with a 1-0 win at Celta Vigo on Sunday.
Barcelona, Real Madrid and Sevilla will be looking to avoid any slip-ups in the La Liga title race this weekend.
Jon Driscoll and Terry Gibson discuss Barcelona's defeat to Deportivo and the goalscoring exploits of Sergio Ramos.
There is no chance of Luis Enrique staying at Barcelona despite their historic Champions League comeback, says Guillem Balague.
Villarreal kept alive their top-four hopes in La Liga with a 2-0 triumph over Espanyol at the Estadio de la Ceramica.
Villarreal maintained their push for Champions League football next season as they comfortably beat Osasuna 4-1 on Wednesday.
Roberto Soldado was saved from embarrassment when he had a penalty saved, only for the referee to blow his whistle for it to be retaken.
Barcelona and Real Madrid are both strong home favourites to build on crucial weekend victories in La Liga on Wednesday.
Real Madrid's penalty against Villarreal was completely unfair, says Sky Sports' Spanish football expert Guillem Balague.
Jon Driscoll and Terry Gibson talk controversy after a weekend of wins for Real Madrid and Barcelona.
Real Madrid returned to the top of La Liga after come from two goals down to win 3-2 at Villarreal on Sunday night.
Zinedine Zidane insists Gareth Bale was taken off as a precaution in Real Madrid's 3-2 win over Villarreal on Sunday.
Relive the action as Real Madrid came back from two goals down to win 3-2 at Villarreal and go back to the top of La Liga.
Lyon cruised through to the last 16 of the Europa League with a thumping 11-2 aggregate win over AZ Alkmaar.
Barcelona visit Atletico Madrid before Real Madrid head to Villarreal in a crucial weekend in the La Liga title race.
Edin Dzeko hit a 21-minute hat-trick as Roma took a 4-0 first-leg advantage in their Europa League last-32 tie against Villarreal.
Real Sociedad missed the chance to move closer to Atletico Madrid and the Champions League places after they were beaten by Villarreal.
The top four may all be short odds to triumph in La Liga but there are sub-plots aplenty as the action hots up this weekend.
Atletico Madrid reclaimed fourth spot in La Liga with a dramatic late 3-2 win over Celta Vigo on Sunday night.