Having given away £250,000 to a Super 6 winner earlier this month, this week's round sees the jackpot upped to £1million for the second time this season.
Here, Soccer Saturday host Jeff Stelling provides his predictions on each featured Super 6 game, along with Sky Bet's most likely outcome according to their correct score odds.
Enter the free-to-play football predictor game before 3pm on Saturday for your chance to become a millionaire.
Aston Villa v Everton
Opta stat: Aston Villa have scored 63 goals in the Barclays Premier League against Everton; 13 more than they have against any other side.
Jeff says: "Benteke to bash Everton, who have won only one of 12 away."
Jeff predicts: Aston Villa 2 Everton 1
Most likely scoreline: Aston Villa 1 Everton 1 - 11/2
Liverpool v West Brom
Opta stat: West Brom have won and kept a clean sheet in each of their last three Barclays Premier League games against Liverpool.
Jeff says: "The Baggies did the double over Liverpool last season and can take a point here."
Jeff predicts: Liverpool 1 West Brom 1
Most likely scoreline: Liverpool 2 West Brom 0 - 13/2
Manchester United v Stoke
Opta stat: Stoke City have lost more Barclays Premier League games against Man Utd than versus any other side (9).
Jeff says: "Rampant Rooney to sink Stoke, who have lost ten in a row at Old Trafford."
Jeff predicts: Man Utd 2 Stoke 0
Most likely scoreline: Man Utd 2 Stoke 0 - 11/2
Norwich v Cardiff
Opta stat: Norwich have lost just one of their last 10 competitive home games against Cardiff City (W7 D2 L1).
Jeff says: "Norwich are better than their league position suggests."
Jeff predicts: Norwich 2 Cardiff 1
Most likely scoreline: Norwich 1 Cardiff 1 - 5/1
Burnley v QPR
Opta stat: Queens Park Rangers have conceded just four goals in their 11 Sky Bet Championship games, less than anyone in the Football Legaue.
Jeff says: "An eighth straight win for Burnley if they can keep old boy Charlie Austin quiet."
Jeff predicts: Burnley 1 QPR 0
Most likely scoreline: Burnley 1 QPR 1 - 5/1
Southampton v Fulham
Opta stat: Fulham are unbeaten in their last seven meetings with Southampton, although five have ended as a draw.
Jeff says: "Southampton are not Crystal Palace - Fulham will find this much harder than their last game."
Jeff predicts: Southampton 2 Fulham 0
Most likely scoreline: Southampton 1 Fulham 0 - 11/2