England will entertain Russia at Tranmere's Prenton Park in their 2019 Women's World Cup qualifying campaign opener in September.
The Lionesses last faced Russia - who sit 20 places below them at 25th in the FIFA rankings - at Euro 2013, drawing 1-1 with a goal from Toni Duggan.
England striker Jodie Taylor, who began her career with Tranmere, said: "I can't wait to go back for this game, it's been a dream of mine for a long time.
"It was at Tranmere that I first started playing properly and it really set me on the path to have the career that I have had.
"Russia are a good team and it will be an excellent test for us to play them at the start of the campaign. We'll want to get off to a strong start and get the three points.
"I know people across Merseyside love their football so hopefully we'll have a big crowd at Prenton Park to really get behind us."
Tranmere Rovers chairman, Mark Palios, added: "We are delighted to be selected as the host venue for what is an important fixture for England Women.
"Tranmere Rovers has a proud history in women's football and we are looking forward to now hosting the national team at Prenton Park.
"It is a great opportunity for the people of the North West to come and support the national team after what we hope will be a successful summer for them.
"With so many Merseyside and North-West players involved, including Jodie Taylor, I am sure the local public will really get behind the team at this fixture and make it a fantastic event."
The match will be played on September 19. England will also face Bosnia & Herzegovina, Kazakhstan and Wales in their World Cup qualifying campaign, with the 2019 finals to be held in France.