England's leading female cricketers will face-off against each other in a series of Twenty20 and 50-over matches at the National Cricket Performance Centre in Loughborough.
The Super 3s tournament will see the top players in the country divided into three teams and play each other on a round-robin basis across both formats.
The event will give the players the opportunity to showcase their talent in front of selectors ahead of series against India and South Africa later this summer.
England skipper Charlotte Edwards and vice-captain Jenny Gunn will lead two of the sides, with 2013 Women's Ashes Player of the Series, Heather Knight, taking charge of the third team.
The T20 tournament will kickstart the action this Saturday and will be followed by a series of 50-over matches to be played on weekends, concluding on June 7.
ECB Head of England Women's Cricket Clare Connor has urged the players taking part to seize their opportunity to impress selectors.
She said: "The Super 3s competition bridges the gap between county and international cricket, bringing together the best female cricketers in the country to enable them to stake a claim for a place in the England women's squad for the summer internationals.
"The competition has evolved since its inception in 2002 and it is a fantastic opportunity for the players to test their skills in a highly competitive environment. It is also a great way for the England women's selectors to judge how the players react under pressure and compare against each other.
"Over the years the competition has been very effective in unearthing fresh new talent, with the likes of Natasha Farrant and Natalie Sciver being the most recent examples of players who have performed well in Super 3s and as a result been called up to the England women's team.
"I wish all of the players involved the best of luck for this weekend, and for the remainder of the competition."