Sheffield United manager Chris Wilder must decide whether to change a winning team following their 3-1 success over Derby on Boxing Day.
Leon Clarke again started on the bench against the Rams but was amongst the scorers with a late strike although he has work to do to dislodge Billy Sharp, who scored his 13th league goal of the season in the win over Derby.
Ryan Nyambe is Blackburn's latest injury concern after the defender was forced off in Wednesday's defeat to Leeds with a hamstring problem, being replaced by Harrison Reed who had recovered from a hamstring strain of his own.
Elliott Bennett - who filled in for Nyambe in October - is out with a foot injury. Craig Conway (muscle), Ben Gladwin and Dominic Samuel (both knee) remain sidelined.
Opta stats
Sheffield United have only lost one of their last six games against Blackburn in the second-tier (W3 D2), though it was a 0-5 drubbing thanks to goals from Matt Jansen, Egil Ostenstad, Ashley Ward and a Damien Duff brace.
Both Blackburn and Sheffield United have won two of their last five league meetings between the two at Bramall Lane, with the last such clash ending 0-0 in September 2006 when both sides were in the Premier League.
No Championship team has lost more points from winning positions this season than Blackburn (19 - Also Aston Villa).
Blackburn haven't lost three consecutive league games since April 2017.
Sheffield United's Oliver Norwood has created more goal-scoring chances than any other player in the Championship this term (59).
Sheffield United striker Billy Sharp has already equalled his league goal tally from last season, netting 13 goals in 22 appearances this term (13 in 34 appearances in 2017-18).
Prutton's prediction
Sheffield United will have been delighted with the way they saw off Derby. It was a big win for them to solidify their play-off position and prove they can last the course this season.
Blackburn won't know how they lost at Leeds but they need a win soon to stop their slump down the table. This is another tough trip and I think the Blades will have too much for them at Bramall Lane.
Prutton predicts: 2-0 (13/2 with Sky Bet)