Carlisle expect to be without Mike Jones for the visit of Sky Bet Championship side Blackburn to Brunton Park.
Jones was forced off with a hamstring injury before half-time in Saturday's draw against Northampton and is unlikely to be risked. Manager John Sheridan is looking for his first win in charge of the Cumbrians but has already indicated he will look to rotate for the midweek encounter.
That should bring the likes of Macauley Gillesphey, Gary Miller and Sam Adewusi into contention, while recent signing Anthony Gerrard may see some action as he looks to build sharpness.
Rovers have ruled out three players ahead of the trip north. Derrick Williams has not recovered from a foot injury, Jacob Davenport (hip) is at least a fortnight away and Ben Gladwin's knee problems continue.
Gladwin has not played since November and is still awaiting his first start for the club. Chelsea loanee Kasey Palmer has been told he will start the game and Dominic Samuel is back after sitting one game out.
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Carlisle and Blackburn haven't met since the first round of the League Cup in 2013-14, when they drew 3-3 and Carlisle progressed on penalties.
Blackburn have been eliminated from all three of their League Cup ties against Carlisle, losing in 1966-67, 1969-70 and 2013-14.
Carlisle have progressed from 10 of their last 12 first round League Cup ties, failing only in 2010-11 (0-1 v Huddersfield) and 2014-15 (0-2 v Derby).
Blackburn haven't been knocked out of the League Cup by a fourth tier side since 1989-90, losing over two legs to Exeter City in the second round. They've progressed from all six ties since then against fourth tier opposition.
Carlisle manager John Sheridan hasn't won any of his last nine League Cup ties, a run stretching back to the 2008-09 season. He last progressed in a League Cup tie in the first round in 2008-09, with his Oldham side winning 4-1 on penalties after a 0-0 draw at Rochdale.