Reggie Lambe and Jevani Brown scored within a minute of each other as lowly Cambridge won 2-0 at Swindon to claim only their third win of the season.
The U's took the lead in the 11th minute after the alert Lambe caught Olly Lancashire dawdling in possession inside his own box before firing home with his left foot.
Cambridge doubled their advantage almost straight from the re-start as Brown ghosted in at the far post to turn in a George Marris cross.
Swindon's night went from bad to worse when influential midfielder Michael Doughty had to be carried off on a stretcher with only 17 minutes on the clock.
Maris came close to making it 3-0 when he lifted a precise shot over Swindon goalkeeper Lawrence Vigouroux and onto the roof of the net.
Swindon striker Marc Richards almost got the hosts back in the game when his 12-yard effort clipped the post.
Kaiyne Woolery was also denied by a smart save from Cambridge goalkeeper David Forde.